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Average moderate to vigorous PA (MVPA) was calculated using accelerometry (min\/d) at baseline and 6, 12, and 24 months. Between\u2010arm MVPA differences according to genotype and genotype with square root\u2013transformed MVPA separately according to arm were tested, stratified according to race, and adjusted for multiple comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>White participants in the PA arm (n=513) had higher average square root transformed MVPA (4.91\u00b11.91)than those in the HE arm (n=538) (4.51\u00b11.82) (p=.001). Between\u2010arm differences were greater for DRD2 Met\/Met (high dopamine; HE: 4.76\u00b11.80, PA: 5.53\u00b11.60, p=.03) than Val\/Val (low dopamine; HE: 4.58\u00b11.92, PA: 4.81\u00b11.83, p=.16); results were similar for COMT. In the PA arm, DRD2 Met\/Met was associated with higher average MVPA (5.39\u00b12.00) than Met\/Val (4.46\u00b12.51) (p=.01) and Val\/Val (4.65\u00b12.71) (p=.01). There were no associations for other genes. Associations were not significant in blacks but followed similar trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher dopamine signaling may support changes in PA during an intervention. The role of dopamine\u2010related pathways in promoting PA participation and enhancing response to interventions in sedentary older adults should be studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      Identifier: NCT01072500\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.15369","type":"journal-article","created":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T21:46:19Z","timestamp":1523396779000},"page":"1172-1179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dopamine\u2010Related Genotypes and Physical Activity Change During an Intervention: The Lifestyle Interventions and Independence for Elders Study"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4467-5304","authenticated-orcid":false,"given":"Andrea L.","family":"Rosso","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Metti","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy W.","family":"Glynn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Boudreau","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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