{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:42:39Z","timestamp":1790012559887,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize antibiotics prescribed to older adults to guide efforts to improve antibiotic use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Descriptive analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Ambulatory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Adults aged 65 and older in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Information on outpatient antibiotic prescriptions dispensed for older adults from 2011 to 2014 was extracted from the IQVIA Xponent database. A chi\u2010square trend analysis was conducted to assess annual changes in antibiotic prescribing rates. A descriptive analysis of prescribing rates by antibiotic, age group, sex, state, Census region, and provider specialty was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 2011 to 2014, outpatient antibiotic prescribing rates remained stable in older U.S. adults (\n                      <jats:italic>P<\/jats:italic>\n                      = .89). In 2014, older adults were dispensed 51.6 million prescriptions (1,115 prescriptions\/1,000 persons). Persons aged 75 and older had a higher prescribing rate (1,157 prescriptions\/1,000 persons) than those aged 65 to 74 (1,084 prescriptions\/1,000 persons). Prescribing rates were highest in the South 1228 prescriptions\/1,000 persons) and lowest in the West (854 prescriptions\/1,000 persons). The most commonly prescribed class was quinolones, followed by penicillins and macrolides. Azithromycin was the most commonly prescribed drug, followed by amoxicillin and ciprofloxacin. Internists and family physicians prescribed 43% of antibiotic courses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>On average, in 2014, U.S. adults aged 65 and older received enough outpatient antibiotic courses for every older adult to receive at least 1. Quinolones and azithromycin are potential targets for assessing the appropriateness of antibiotic prescribing in this population. Interventions to improve use targeting internists and family physicians in the South Census region might have the potential to have the greatest effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.15518","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T08:11:26Z","timestamp":1537171886000},"page":"1998-2002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Outpatient Antibiotic Prescribing for Older Adults in the United States: 2011 to 2014"],"prefix":"10.1111","volume":"66","author":[{"given":"Sarah","family":"Kabbani","sequence":"first","affiliation":[{"name":"Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Palms","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monina","family":"Bartoces","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimalie","family":"Stone","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauri A.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Division of Healthcare Quality Promotion Centers for Disease Control and Prevention Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,17]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Centers for Disease Control and Prevention. Antibiotic Resistant Threats in the United States 2013 (online). Available athttp:\/\/www.cdc.gov\/drugresistance\/threat-report-2013Accessed August 24 2016."},{"key":"e_1_2_6_3_1","unstructured":"Centers for Disease Control and Prevention. The State of Aging and Health in America 2013 (online). Available athttp:\/\/www.cdc.gov\/aging\/pdf\/state-aging-health-in-america-2013.pdfAccessed August 24 2016."},{"key":"e_1_2_6_4_1","unstructured":"WHO. Global Action Plan on Antimicrobial Resistance 2014 (online). Available athttp:\/\/apps.who.int\/iris\/bitstream\/10665\/112642\/1\/9789241564748_eng.pdfAccessed August 30 2016."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu543"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1411.070467"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.16201"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408913"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/428125"},{"key":"e_1_2_6_10_1","unstructured":"Centers for Disease Control and Prevention. Antibiotic Resistance Patient Safety Atlas (online). Available athttps:\/\/gis.cdc.gov\/grasp\/PSA\/indexAU.htmlAccessed May 8 2018."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-12-96"},{"key":"e_1_2_6_12_1","unstructured":"U.S Census Bureau. Census Regions and Divisions of the United States (online). Available athttp:\/\/www2.census.gov\/geo\/pdfs\/maps-data\/maps\/reference\/us_regdiv.pdfAccessed May 8 2018."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-2091-0"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/501798"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20170100"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-015-0768-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm032"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-011-0129-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1093\/cid\/civ076","article-title":"US outpatient antibiotic prescribing variation according to geography, patient population, and provider specialty in 2011","volume":"60","author":"Hicks LA","year":"2015","journal-title":"Clin Infect Dis"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2012.3717"},{"key":"e_1_2_6_21_1","first-page":"519","article-title":"Variation in US outpatient antibiotic prescribing quality measures according to health plan and geography","volume":"22","author":"Roberts RM","year":"2016","journal-title":"Am Manag Care"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3507"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1010220"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.2089"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4021"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.4151"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.6625"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-1131"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2217\/ahe.13.38"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(03)00005-9"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw159"},{"key":"e_1_2_6_32_1","unstructured":"U.S. Food and Drug Administration. 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