{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:38:50Z","timestamp":1790264330827,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["Grant MOP\u2010326559"],"award-info":[{"award-number":["Grant MOP\u2010326559"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate whether risk of fall\u2010related injuries differs between nursing home (NH) residents newly dispensed low\u2010dose trazodone and those newly dispensed benzodiazepines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective, matched cohort study in linked, population\u2010based administrative data. Matching was based on propensity score (\u2009\u00b1\u20090.2 standard deviations of the score as a caliper), age (\u2009\u00b1\u20091 year), sex, frailty status, and history of dementia. The derived propensity score included demographic characteristics, clinical comorbidities, cognitive and functional status, and risk factors for falls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>All NHs in Ontario, Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Propensity score\u2013matched pairs of residents aged 66 and older who received a full clinical assessment between April 1, 2010, and March 31, 2015 (N=7,791).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Hospitalization (emergency department visit or acute care admission) for a fall\u2010related injury within 90 days of exposure. Subdistribution hazard functions accounted for competing risk of death. Sensitivity analyses were used to examine falls resulting in hip or wrist fracture only, as well as different lengths of follow\u2010up at 30, 60, and 180 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cumulative incidence of a fall\u2010related injury in the 90 days after index was 5.7% for low\u2010dose trazodone users and 6.0% for benzodiazepine users (between\u2010group change=\u20130.29, 95% confidence interval (CI)=\u20131.02\u20130.44]; hazard ratio=0.94, 95% CI=0.83\u20131.08). Findings were consistent across sensitivity analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>New use of low\u2010dose trazodone was no safer with respect to a risk of a fall\u2010related injury than new use of benzodiazepines. Additional studies to compare the effectiveness and risks of low\u2010dose trazodone with those of a variety of psychotropic drug therapies are required in light of increasing trends in the use of trazodone in NHs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.15519","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T08:45:31Z","timestamp":1537778731000},"page":"1963-1971","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Low\u2010Dose Trazodone, Benzodiazepines, and Fall\u2010Related Injuries in Nursing Homes: A Matched\u2010Cohort Study"],"prefix":"10.1111","volume":"66","author":[{"given":"Susan E.","family":"Bronskill","sequence":"first","affiliation":[{"name":"Institute for Clinical Evaluative Sciences Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada"},{"name":"Women's College Research Institute, Women's College Hospital Toronto Ontario Canada"},{"name":"Sunnybrook Research Institute, Sunnybrook Health Sciences Centre Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Campitelli","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Iaboni","sequence":"additional","affiliation":[{"name":"Toronto Rehabilitation Institute University Health Network Toronto Ontario Canada"},{"name":"Departments of Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute, Sunnybrook Health Sciences Centre Toronto Ontario Canada"},{"name":"Departments of Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Guan","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Maclagan","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Watt","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada"},{"name":"Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula A.","family":"Rochon","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada"},{"name":"Women's College Research Institute, Women's College Hospital Toronto Ontario Canada"},{"name":"Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Morris","sequence":"additional","affiliation":[{"name":"Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne","family":"Jeffs","sequence":"additional","affiliation":[{"name":"Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health University of Toronto Toronto Ontario Canada"},{"name":"Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaim M.","family":"Bell","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences Toronto Ontario Canada"},{"name":"Medicine University of Toronto Toronto Ontario Canada"},{"name":"Divisions of General Internal Medicine and Infectious Diseases, Sinai Health System Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen J.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences Toronto Ontario Canada"},{"name":"Schools of Pharmacy"},{"name":"Public Health and Health Systems University of Waterloo Waterloo Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13702"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5414\/CPP46072"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv091"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2000.tb04729.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15016"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122246"},{"key":"e_1_2_6_8_1","unstructured":"American Geriatrics Society.Don't Use Benzodiazepines or Other Sedative\u2010Hypnotics in Older Adults As First Choice for Insomnia Agitation or Delirium (online). Available athttp:\/\/www.choosingwisely.org\/clinician-lists\/american-geriatrics-society-benzodiazepines-sedative-hypnotics-for-insomnia-in-older-adults\/Accessed September 20 2017."},{"key":"e_1_2_6_9_1","unstructured":"RTI International. MDS 3.0 Quality Measures User's Manual (online). Available athttps:\/\/www.cms.gov\/Medicare\/Quality-Initiatives-Patient-Assessment-Instruments\/NursingHomeQualityInits\/Downloads\/MDS-30-QM-Users-Manual-V10.pdfAccessed September 20 2017."},{"key":"e_1_2_6_10_1","unstructured":"Health Quality Ontario. Benzodiazepines: Percentage of Residents Aged 66 and Older Who Were Prescribed a Benzodiazepine (online). Available athttp:\/\/indicatorlibrary.hqontario.ca\/Indicator\/Detailed\/LTCPR-falls-BDZ\/ENAccessed September 20 2017."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3825"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-017-1254-x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2015.07.001"},{"key":"e_1_2_6_14_1","unstructured":"American Geriatrics Society.Ten Things Clinicians and Patients Should Question (online). Available athttp:\/\/www.choosingwisely.org\/wp\u2010content\/uploads\/2015\/02\/AGS\u2010Choosing\u2010Wisely\u2010List.pdfAccessed November 1 2017."},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-016-0380-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-012-0003-6"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2010.09.005"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j603"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcgg.2013.12.001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.9.1271"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.12.174"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-199705010-00008"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.930090112"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2016.09.010"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt201"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2017.08.014"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d4551"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1983.tb02180.x"},{"key":"e_1_2_6_29_1","article-title":"Trazodone in the elderly: Risk of extrapyramidal acute events","volume":"2015","author":"Sotto MJ","year":"2015","journal-title":"BMJ Case Report"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-8-277"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1027\/00496-000"},{"key":"e_1_2_6_32_1","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology. ATC\/DDD Index 2017 (online). Available athttps:\/\/www.whocc.no\/atc_ddd_index\/Accessed November 1 2017."},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.2147\/DHPS.S64359"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5398"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2008.02048.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/29.2.165"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.4.M174"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017719"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5984"},{"key":"e_1_2_6_41_1","first-page":"CD009178","article-title":"Pharmacotherapies for sleep disturbances in dementia","volume":"11","author":"McCleery J","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.13995"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.04.027"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-013-0151-3"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b3999"},{"key":"e_1_2_6_46_1","first-page":"498","article-title":"Off\u2010label applications for SSRIs","volume":"68","author":"Stone KJ","year":"2003","journal-title":"Am Fam Physician"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.6058"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.03923.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/1054773811414180"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.03.015"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd12.150187"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14759"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-015-1955-3"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174730"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.14.1270"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.15519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.15519","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgs.15519","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.15519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:39:32Z","timestamp":1762187972000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.15519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,24]]},"references-count":54,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/jgs.15519"],"URL":"https:\/\/doi.org\/10.1111\/jgs.15519","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,24]]},"assertion":[{"value":"2018-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}