{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:36:24Z","timestamp":1793900184394,"version":"4.8.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To summarize evidence on cognitive outcomes after heart valve surgery; secondary aim, to examine whether aortic and mitral valve surgery are associated with different cognitive outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses systematic review and meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Individuals undergoing heart valve surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      We searched MEDLINE, EMBASE, and PsycINFO for peer\u2010reviewed reports of individuals undergoing heart valve surgery who underwent pre\u2010 and postoperative cognitive assessment. Our initial search returned 1,475 articles, of which 12 were included. Postoperative cognitive results were divided into those from 1 week to 1 month (early outcomes,\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>pooled<\/jats:sub>\n                      \u2009=\u2009450) and from 2 to 6 months (intermediate outcomes;\n                      <jats:italic>n<\/jats:italic>\n                      <jats:sub>pooled<\/jats:sub>\n                      \u2009=\u2009722). No studies with longer\u2010term outcomes were identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Subjects had moderate early cognitive decline from baseline (Becker mean gain effect size (ES)=\u22120.39\u2009\u00b1\u20090.27) that improved slightly by 2 to 6 months (ES=\u20130.25\u2009\u00b1\u20090.38). Individuals undergoing aortic valve surgery\u2014who were older on average than those undergoing mitral valve surgery (68 vs 57)\u2014had greater early cognitive decline than those undergoing mitral valve surgery (ES=\u20130.68 vs \u22120.12), but both cohorts had similar decline 2 to 6 months postoperatively (ES=\u20130.27 vs \u22120.20).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Heart valve surgery is associated with cognitive decline over the 6 months after surgery, but outcomes beyond 6 months are unclear. These findings highlight the cognitive vulnerability of this population, especially older adults with aortic stenosis. \u00a9 2018 American Geriatrics Society and Wiley Periodicals, Inc.\n                      <jats:bold>J Am Geriatr Soc 66:2327\u20132334, 2018<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.15601","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T07:58:31Z","timestamp":1539244711000},"page":"2327-2334","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Cognitive Outcomes After Heart Valve Surgery: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"66","author":[{"given":"Mark A.","family":"Oldham","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Rochester Medical Center  Rochester New 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