{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:50:37Z","timestamp":1769086237825,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T00:00:00Z","timestamp":1545609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To establish consensus recommendations for empirical treatment of uncomplicated cystitis with anti\u2010infectives in noncatheterized older nursing home residents to be implemented in the Improving Outcomes of UTI Management in Long\u2010Term Care Project (IOU) funded by the Agency for Healthcare Research and Quality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>Two\u2010round modified Delphi survey.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>Expert panel of 19 clinical pharmacists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS<\/jats:title>\n                    <jats:p>Comprehensive literature search and development\/review\/edit of draft survey by the investigative group (one geriatric clinical pharmacist, two geriatric medicine physicians, and one infectious disease physician). The expert panel members rated their agreement with each of 31 recommendations for drugs of choice, dosing medications at various levels of renal function, drug\u2010drug interactions to avoid, and duration of therapy by sex on a 5\u2010point Likert scale (1 = strongly disagree to 5 = strongly agree). Consensus agreement was defined as a lower 95% confidence limit of 4.0 or higher for the recommendation\u2010specific mean score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The response rate was 95% for the first round, and three recommendations achieved consensus (dosing for nitrofurantoin and trimethoprim\/sulfamethoxazole in those without chronic kidney disease, and drug\u2010drug interaction between trimethoprim\/sulfamethoxazole and warfarin). In the second round, 90% responded and reached consensus on an additional eight recommendations (two for nitrofurantoin or trimethoprim\/sulfamethoxazole as initial drugs of choice, three for dosing ciprofloxacin, nitrofurantoin, and trimethoprim\/sulfamethoxazole at various levels of chronic kidney disease, and three drug\u2010drug interactions to avoid: trimethoprim\/sulfamethoxazole with phenytoin and ciprofloxacin with theophylline or with tizanidine).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>An expert panel of clinical pharmacists was able to reach consensus on a set of recommendations for the empirical treatment of cystitis with oral anti\u2010infective medications in older nursing home residents. The recommendations were incorporated into a treatment algorithm for uncomplicated cystitis in noncatheterized nursing home residents and used in educational materials for health professionals in an ongoing controlled intervention study. J Am Geriatr Soc 67:539\u2013545, 2019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.15726","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T20:43:27Z","timestamp":1545684207000},"page":"539-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The IOU Consensus Recommendations for Empirical Therapy of Cystitis in Nursing Home Residents"],"prefix":"10.1111","volume":"67","author":[{"given":"Joseph T.","family":"Hanlon","sequence":"first","affiliation":[{"name":"Division of Geriatric Medicine, Department of Medicine (Geriatrics) University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"Department of Pharmacy and Therapeutics, School of Pharmacy University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"Geriatric Research Education and Clinical Center (GRECC) Veterans Affairs Pittsburgh Healthcare System (VAPHS) Pittsburgh Pennsylvania"},{"name":"Center for Health Equity Research and Promotion (CHERP) VAPHS Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subashan","family":"Perera","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine, Department of Medicine (Geriatrics) University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"Department of Biostatistics, School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Drinka","sequence":"additional","affiliation":[{"name":"Divisions of Internal Medicine and Geriatric Medicine University of Wisconsin Madison Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Crnich","sequence":"additional","affiliation":[{"name":"Infectious Disease, Department of Medicine, School of Medicine and Public Health University of Wisconsin Madison Wisconsin"},{"name":"William S. 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