{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:58:59Z","timestamp":1791215939534,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["K24 AG056589"],"award-info":[{"award-number":["K24 AG056589"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 CA177592"],"award-info":[{"award-number":["R01 CA177592"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["UG1 CA189961"],"award-info":[{"award-number":["UG1 CA189961"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["4634"],"award-info":[{"award-number":["4634"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008091","name":"University of Rochester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>To evaluate the relationships between aging\u2010related domains captured by geriatric assessment (GA) for older patients with advanced cancer and caregivers\u2019 emotional health and quality of life (QOL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>In this cross sectional study of baseline data from a nationwide investigation of older patients and their caregivers, patients completed a GA that included validated tests to evaluate eight domains of health (eg, function, cognition).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>Thirty\u2010one community oncology practices throughout the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>Enrolled patients were aged 70 and older, had one or more GA domain impaired, and had an incurable solid tumor malignancy or lymphoma. Each could choose one caregiver to enroll.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS<\/jats:title>\n                    <jats:p>Caregivers completed the Generalized Anxiety Disorder\u20107, Distress Thermometer, Patient Health Questionnaire\u20102 (depression), and Short Form Health Survey\u201012 (SF\u201012 for QOL). Separate multivariate linear or logistic regression models were used to examine the association of the number and type of patient GA impairments with caregiver outcomes, controlling for patient and caregiver covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A total of 541 patients were enrolled, 414 with a caregiver. Almost half (43.5%) of the caregivers screened positive for distress, 24.4% for anxiety, and 18.9% for depression. Higher numbers of patient GA domain impairments were associated with caregiver depression (adjusted odds ratio [aOR]\u2009=\u20091.29;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001], caregiver physical health on SF\u201012 (regression coefficient [\u03b2]\u2009=\u2009\u22121.24;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), and overall caregiver QOL (\u03b2\u2009=\u2009\u22121.14;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01). Impaired patient function was associated with lower caregiver QOL (\u03b2 = \u22124.11;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Impaired patient nutrition was associated with caregiver depression (aOR\u2009=\u20092.08;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01). Lower caregiver age, caregiver comorbidity, and patient distress were also associated with worse caregiver outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Patient GA impairments were associated with poorer emotional health and lower QOL of caregivers. J Am Geriatr Soc 67:969\u2013977, 2019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.15862","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T07:02:31Z","timestamp":1553842951000},"page":"969-977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Quality of Life of Caregivers of Older Patients with Advanced Cancer"],"prefix":"10.1111","volume":"67","author":[{"given":"Lee A.","family":"Kehoe","sequence":"first","affiliation":[{"name":"URCC NCORP Research Base University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiwen","family":"Xu","sequence":"additional","affiliation":[{"name":"URCC NCORP Research Base University of Rochester Medical Center  Rochester New York"},{"name":"Department of Public Health Sciences University of Rochester School of Medicine  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Duberstein","sequence":"additional","affiliation":[{"name":"Rutgers School of Public Health  New Brunswick New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kah Poh","family":"Loh","sequence":"additional","affiliation":[{"name":"URCC NCORP Research Base University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Culakova","sequence":"additional","affiliation":[{"name":"URCC NCORP Research Base University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly","family":"Canin","sequence":"additional","affiliation":[{"name":"SCOREboard Advisory Group University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Hurria","sequence":"additional","affiliation":[{"name":"City of Hope National Medical Center  Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Dale","sequence":"additional","affiliation":[{"name":"University of North Carolina  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Wells","sequence":"additional","affiliation":[{"name":"URCC NCORP Research Base University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikesha","family":"Gilmore","sequence":"additional","affiliation":[{"name":"URCC NCORP Research Base University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber S.","family":"Kleckner","sequence":"additional","affiliation":[{"name":"URCC NCORP Research Base University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lund","sequence":"additional","affiliation":[{"name":"University of North Carolina  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Kamen","sequence":"additional","affiliation":[{"name":"URCC NCORP Research Base University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Flannery","sequence":"additional","affiliation":[{"name":"URCC NCORP Research Base University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Hoerger","sequence":"additional","affiliation":[{"name":"Tulane University  New Orleans Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith O.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Southeast Clinical Oncology Research (SCOR) Consortium NCI Community Oncology Research Program (NCORP), Winston Salem, North Carolina; Novant Health\u2010GWSM"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Jijun","family":"Liu","sequence":"additional","affiliation":[{"name":"Heartland NCORP  Decatur Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi","family":"Geer","sequence":"additional","affiliation":[{"name":"Metro\u2010Minnesota NCORP  St. Louis Park Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Epstein","sequence":"additional","affiliation":[{"name":"URCC NCORP Research Base University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya G.","family":"Mohile","sequence":"additional","affiliation":[{"name":"URCC NCORP Research Base University of Rochester Medical Center  Rochester New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29939"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnu177"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28765"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2014.09.003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.2104"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269216318793286"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2016.12.001"},{"issue":"4","key":"e_1_2_6_9_1","first-page":"25","article-title":"Family caregivers of elderly patients with cancer: understanding and minimizing the burden of care","volume":"1","author":"Haley WE","year":"2003","journal-title":"J Support Oncol"},{"key":"e_1_2_6_10_1","volume-title":"Geriatric Psycho\u2010Oncology: A Quick Reference on the Psychological Dimensions of Cancer Symptom Management","author":"Given BA","year":"2015"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/08952841.2016.1223962"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.0909"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1057\/9781137558985_2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-200603000-00007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NCC.0000305760.04357.96"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.5798"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2016.02.007"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.8687"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2015.0137"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suponc.2011.10.003"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(94)00249-S"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0898264304274179"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.18_suppl.LBA10003"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30269"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324731"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLR.0000093487.78664.3C"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.993"},{"key":"e_1_2_6_29_1","volume-title":"NCCN Distress Thermometer and Problem List for Patients","author":"National Comprehensive Cancer Network","year":"2016"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199603000-00003"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30875"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2012.09.004"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/07347332.2014.1002657"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0085"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2004.04.018"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12691"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2016.03.003"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2012.06.013"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12833"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2018.01.003"},{"key":"e_1_2_6_41_1","first-page":"S130","article-title":"Missed Opportunities to Discuss Patient and Caregiver Aging Concerns in Oncology Clinical Encounters","volume":"49","author":"Lowenstein L","year":"2015","journal-title":"Annals of Behavioral Medicine"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2018.02.007"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2009.02513.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2018.04.007"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090198117705164"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0432"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0009"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8347"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30053"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0159"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2017.05.002"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-2-8"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pec.2017.05.014"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.3434"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14023"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.15862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.15862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgs.15862","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.15862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T12:39:55Z","timestamp":1762173595000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.15862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,29]]},"references-count":54,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/jgs.15862"],"URL":"https:\/\/doi.org\/10.1111\/jgs.15862","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,29]]},"assertion":[{"value":"2018-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}