{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:16:59Z","timestamp":1781785019458,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RC4 CA153828"],"award-info":[{"award-number":["RC4 CA153828"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2019,5]]},"abstract":"\n BACKGROUND\/OBJECTIVES<\/jats:title>\n Women diagnosed with breast cancer (BC) at an older age are less likely to undergo genetic cancer risk assessment and genetic testing since the guidelines and referrals are biased toward earlier age at diagnosis. Thus, we determined the prevalence and type of pathogenic cancer predisposition variants among women with a history of BC diagnosed at the age\u2009of 65 years or older vs younger than 65\u2009years.<\/jats:p>\n <\/jats:sec>\n \n DESIGN<\/jats:title>\n Prospective registration cohort.<\/jats:p>\n <\/jats:sec>\n \n SETTING<\/jats:title>\n The Clinical Cancer Genomics Community Research Network, including 40 community\u2010based clinics in the United States and 5 in Latin America.<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS<\/jats:title>\n Women with BC and genetic testing results.<\/jats:p>\n <\/jats:sec>\n \n MEASUREMENTS<\/jats:title>\n Sociodemographic characteristics, clinical variables, and genetic profiles were compared between women aged 65 years and older and\u2009those younger than 65\u2009years at BC diagnosis.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Among 588 women diagnosed with BC and aged 65\u2009years and older and 9412 diagnosed at younger than 65\u2009years, BC\u2010associated pathogenic variants (PVs) were detected in 5.6% of those aged 65 years and older (n\u2009=\u200933) and 14.2% of those younger than 65\u2009years (n\u2009=\u20091340) (\n P<\/jats:italic>\n \u2009<\u2009.01). PVs in high\u2010risk genes (eg,\n BRCA1<\/jats:italic>\n and\n BRCA2<\/jats:italic>\n ) represented 81.1% of carriers among women aged 65\u2009years and older (n\u2009=\u200927) and 93.1% of those younger than 65\u2009years (n\u2009=\u20091248) (\n P<\/jats:italic>\n \u2009=\u2009.01).\n BRCA2<\/jats:italic>\n PVs represented 42.4% of high\u2010risk gene findings for those aged 65\u2009years and older, whereas\n BRCA1<\/jats:italic>\n PVs were most common among carriers younger than 65\u2009years (49.7%). PVs (n\u2009=\u20097) in moderate\u2010risk genes represented 21.2% for carriers aged 65 years and older and 7.3% of those younger than 65 years (n\u2009=\u200998;\n P<\/jats:italic>\n \u2009<\u2009.01).\n CHEK2<\/jats:italic>\n PVs were the most common moderate\u2010risk gene finding in both groups.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n Clinically actionable BC susceptibility PVs, particularly in\n BRCA2<\/jats:italic>\n and\n CHEK2<\/jats:italic>\n , were relatively prevalent among older women undergoing genetic testing. The significant burden of PVs for older women with BC provides a critical reminder to recognize the full spectrum of eligibility and provide genetic testing for older women, rather than exclusion based on chronological age alone. J Am Geriatr Soc 67:884\u2013888, 2019.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.15937","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T11:37:34Z","timestamp":1556019454000},"page":"884-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Burden of Breast Cancer Predisposition Variants Across The Age Spectrum Among 10 000 Patients"],"prefix":"10.1111","volume":"67","author":[{"given":"Yanin","family":"Chavarri\u2010Guerra","sequence":"first","affiliation":[{"name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn B.","family":"Hendricks","sequence":"additional","affiliation":[{"name":"Maryland Oncology Hematology Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Brown","sequence":"additional","affiliation":[{"name":"St. Joseph Hospital and Mission Hospital Orange California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Marcum","sequence":"additional","affiliation":[{"name":"High Risk Genetics, Survivorship APN Chattanooga Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Hander","sequence":"additional","affiliation":[{"name":"Kootenai Clinic Cancer Services Coeur d'Alene Idaho"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zdenka E.","family":"Segota","sequence":"additional","affiliation":[{"name":"Holy Cross Medical Group Fort Lauderdale Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Hake","sequence":"additional","affiliation":[{"name":"Waukesha Memorial Hospital\u2010ProHealth Care Research Institute Waukesha Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Sand","sequence":"additional","affiliation":[{"name":"Clinical Cancer Genomics, City of Hope Comprehensive Cancer Center Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Slavin","sequence":"additional","affiliation":[{"name":"Clinical Cancer Genomics, City of Hope Comprehensive Cancer Center Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arti","family":"Hurria","sequence":"additional","affiliation":[{"name":"Clinical Cancer Genomics, City of Hope Comprehensive Cancer Center Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-2163","authenticated-orcid":false,"given":"Enrique","family":"Soto\u2010Perez\u2010de\u2010Celis","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n, Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bita","family":"Nehoray","sequence":"additional","affiliation":[{"name":"Clinical Cancer Genomics, City of Hope Comprehensive Cancer Center Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth B.","family":"Blankstein","sequence":"additional","affiliation":[{"name":"Hunterdon Hematology Oncology Flemington New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen R.","family":"Blazer","sequence":"additional","affiliation":[{"name":"Clinical Cancer Genomics, City of Hope Comprehensive Cancer Center Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6714-092X","authenticated-orcid":false,"given":"Jeffrey N.","family":"Weitzel","sequence":"additional","affiliation":[{"name":"Clinical Cancer Genomics, City of Hope Comprehensive Cancer Center Duarte California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Clinical Cancer Genomics Community Research Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"FerlayJ SoerjomataramI ErvikM et al.GLOBOCAN 2012 v1.1 Cancer Incidence and Mortality Worldwide: IARC CancerBase. 2012.http:\/\/globocan.iarc.fr. 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