{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:36:33Z","timestamp":1792143393881,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T35AG026736"],"award-info":[{"award-number":["T35AG026736"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 MH113406"],"award-info":[{"award-number":["R01 MH113406"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NR015223"],"award-info":[{"award-number":["R01 NR015223"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Nearly half of the population living with human immunodeficiency virus (HIV) in the United States is now older than 50 years with at least 6% over age 65. Between 35% and 50% live with mild to moderate cognitive impairment. Older persons living with HIV (PLWH) also have a substantial burden of HIV\u2010associated non\u2010acquired immunodeficiency syndrome medical conditions and are at risk for frailty, geriatric syndromes, and early mortality compared with HIV\u2010uninfected peers. We sought to define the magnitude of geriatric conditions and multimorbidity in PLWH older than 60 years who are living with symptomatic cognitive impairment. In a subset of participants, we examined associations between these geriatric conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>HIV Elders Study at the University of California, San Francisco, Memory and Aging Center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Participants were HIV infected, virally suppressed, 60\u2009years or older, and clinically diagnosed with mild neurocognitive disorder (MND).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>We conducted standardized assessment of geriatric conditions and everyday function and investigated multimorbidity burden using the Veterans Aging Cohort Study (VACS) index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 141 older PLWH with MND, 58% report incontinence, 55% meet criteria for pre\u2010frailty, and a substantial proportion report dependence with instrumental activities of daily living (52%) or activities of daily living (41%). The mean VACS index score is 33 (standard deviation = 14), suggesting a 13.8% 5\u2010year all\u2010cause mortality risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Older PLWH with symptomatic cognitive impairment carry a substantial burden of other geriatric conditions. Our work supports the need for comprehensive geriatric systems of care for cognitively impaired individuals aging with HIV.\n                      <jats:bold>J Am Geriatr Soc 67:1913\u20131916, 2019<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16034","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T11:44:41Z","timestamp":1561549481000},"page":"1913-1916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Geriatric Syndromes in Older Adults Living with HIV and Cognitive Impairment"],"prefix":"10.1111","volume":"67","author":[{"given":"Kalei R.J.","family":"Hosaka","sequence":"first","affiliation":[{"name":"Department of Tropical Medicine John A. Burns School of Medicine, University of Hawaii Honolulu Hawaii"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith","family":"Greene","sequence":"additional","affiliation":[{"name":"Division of Geriatrics University of California San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Premeaux","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine John A. Burns School of Medicine, University of Hawaii Honolulu Hawaii"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shireen","family":"Javandel","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology University of California San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel E.","family":"Allen","sequence":"additional","affiliation":[{"name":"Memory and Aging Center, Department of Neurology University of California San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lishomwa C.","family":"Ndhlovu","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine John A. Burns School of Medicine, University of Hawaii Honolulu Hawaii"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Valcour","sequence":"additional","affiliation":[{"name":"Division of Geriatrics University of California San Francisco California"},{"name":"Memory and Aging Center, Department of Neurology University of California San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31825a3668"},{"key":"e_1_2_6_3_1","unstructured":"HIV Among People Aged 50 and Over. 2018.https:\/\/www.cdc.gov\/hiv\/group\/age\/olderamericans\/index.html. 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