{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:51:09Z","timestamp":1787838669248,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","award":["17\u2010R115\u2010A7443\u201022062"],"award-info":[{"award-number":["17\u2010R115\u2010A7443\u201022062"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007405","name":"Hjerteforeningen","doi-asserted-by":"publisher","award":["16\u2010R107\u2010A6776\u201022972"],"award-info":[{"award-number":["16\u2010R107\u2010A6776\u201022972"]}],"id":[{"id":"10.13039\/100007405","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Management of atrial fibrillation (AF) with rate and\/or rhythm control could lead to fall\u2010related injuries and syncope, especially in the older AF population. We aimed to determine the association of rate and\/or rhythm control with fall\u2010related injuries and syncope in a real\u2010world older AF cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>A retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>Danish nationwide administrative registries from 2000 to 2015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>A total of 100 935 patients with AF aged 65\u2009years or older claiming prescription of rate\u2010lowering drugs (RLDs) and\/or anti\u2010arrhythmic drugs (AADs) were included. We compared the use of rate\u2010lowering monotherapy with rate\u2010lowering dual therapy, AAD monotherapy, and AAD combined with rate\u2010lowering therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS<\/jats:title>\n                    <jats:p>Outcomes were fall\u2010related injuries and syncope as a composite end point (primary) or separate end point (secondary).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In this population, the median age was 78\u2009years (interquartile range [IQR] = 72\u201084 y), and 53 481 (53.0%) were women. During a median follow\u2010up of 2.1 years (IQR = 1.0\u20105.1), 17 132 (17.0%) experienced a fall\u2010related injury, 5745 (5.7%) had a syncope, and 21 093 (20.9%) experienced either. Compared with rate\u2010lowering monotherapy, AADs were associated with a higher risk of fall\u2010related injuries and syncope. The incidence rate ratio (IRR) for the composite end point was 1.29 (95% confidence interval [CI]: 1.17\u20101.43) for AAD monotherapy and 1.46 [95% CI = 1.34\u20101.58] for AAD combined with rate\u2010lowering therapy. When stratifying by individual drugs, amiodarone significantly increased the risk of fall\u2010related injuries and syncope (IRR = 1.40 [1.26\u20101.55]). Compared with more than 180\u2009days of rate\u2010lowering monotherapy, a higher risk of all outcomes was seen in the first 90\u2009days of any treatment; however, the greatest risk was in the first 14\u2009days for those treated with AADs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      In AF patients aged 65\u2009years and older, AAD use was associated with a higher risk of fall\u2010related injuries and syncope, and the risk was highest within the first 14\u2009days for those treated with AADs. Only amiodarone use was associated with a higher risk.\n                      <jats:bold>J Am Geriatr Soc 67:2023\u20132030, 2019<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16062","type":"journal-article","created":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T07:36:13Z","timestamp":1563953773000},"page":"2023-2030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Rate or Rhythm Control in Older Atrial Fibrillation Patients: Risk of Fall\u2010Related Injuries and Syncope"],"prefix":"10.1111","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7287-4191","authenticated-orcid":false,"given":"Frederik","family":"Dalgaard","sequence":"first","affiliation":[{"name":"Department of Cardiology Herlev and Gentofte Hospital Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannik 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