{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:16:01Z","timestamp":1768450561772,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>To evaluate the dose\u2010response relationships between alcohol consumption and functional limitations in older European men, and explore the role of muscle strength as a mediator of these relationships.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>Cross\u2010sectional study of older men participating in the Survey of Health, Aging and Retirement in Europe (SHARE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>Urban and rural households in 17 European countries and Israel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>A total of 17\u2009870 men aged 65\u2009years and older from the SHARE (Wave 6,\u20092015) were included in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS<\/jats:title>\n                    <jats:p>Outcome variables were functional limitations: mobility limitation, arm function limitation, and fine motor limitation. Main exposure variable was alcohol consumption. Mediating factor was grip strength. Basic demographics, life habits, and health status were considered as potential confounders. Dose\u2010response analyses with restricted cubic splines and the Karlson\/Holm\/Breen method were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A total of 17 870 participants were included in this study. Dose\u2010response analyses revealed that moderate alcohol consumption was related to the lower odds of reporting mobility limitation (\u226435\u2009units\/wk) and arm function limitation (\u226441\u2009units\/wk), with a minimum odds ratio (OR) occurring at 10 units\/week drinks for mobility limitation (OR = .71; 95% confidence interval [CI] = .62\u2010.81) and arm function limitation (OR = .66; 95% CI = .59\u2010.75). The odds of reporting the fine motor limitation monotonically increased with alcohol consumption when alcohol consumption was beyond 15\u2009units\/week. No significant mediating effect of grip strength on the relationships between alcohol consumption and mobility limitation and arm function limitation was found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Moderate alcohol consumption has a protective role in mobility and arm function limitation in older European men. Grip strength is not the main mediator of these associations, suggesting that the protective effect is independent of muscle strength. Alcohol consumption is associated with higher odds of reporting fine motor limitation in older European men.\n                      <jats:bold>J Am Geriatr Soc 67:2331\u20132337, 2019<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16082","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T09:51:40Z","timestamp":1564739500000},"page":"2331-2337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Alcohol Consumption and Functional Limitations in Older Men: Does Muscle Strength Mediate Them?"],"prefix":"10.1111","volume":"67","author":[{"given":"Tong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics Public Health College, Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suyun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics Public Health College, Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology Affiliated Hospital of Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongye","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition Public Health College, Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics Public Health College, Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5289-2552","authenticated-orcid":false,"given":"Yili","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics Public Health College, Qingdao University Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01339.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113196660060"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.08.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.08.015"},{"key":"e_1_2_6_6_1","unstructured":"Functional and Activity Limitations Statistics \u2010 Statistics Explained.https:\/\/ec.europa.eu\/eurostat\/statistics-explained\/index.php?title=Functional_and_activity_limitations_statistics. 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