{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:34:49Z","timestamp":1788690889882,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["Dr. Nanna is funded by NIH T\u201032\u2010HL069749\u201015"],"award-info":[{"award-number":["Dr. Nanna is funded by NIH T\u201032\u2010HL069749\u201015"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["Dr. Navar is funded by NIH K01HL133416\u201001"],"award-info":[{"award-number":["Dr. Navar is funded by NIH K01HL133416\u201001"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND\/OBJECTIVES<\/jats:title>\n                    <jats:p>Elevated low\u2010density lipoprotein cholesterol (LDL\u2010C) in early adulthood is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). The strength of the association between LDL\u2010C and ASCVD among older adults, however, is less understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>We examined individual\u2010level cohort data from the National Institutes of Health Pooled Cohorts (Framingham Study, Framingham Offspring Study, Multi\u2010Ethnic Study of Atherosclerosis, and Cardiovascular Health Study), which prospectively measured CVD risk factors and incident disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>Adults, aged 75\u2009years or older, free of ASCVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS<\/jats:title>\n                    <jats:p>We evaluated the associations between LDL\u2010C and incident ASCVD (stroke, myocardial infarction, and cardiovascular death) in unadjusted analysis and in multivariable\u2010adjusted Cox proportional hazards models. We assessed 5\u2010year Kaplan\u2010Meier ASCVD event rates in patients with and without hyperlipidemia (LDL\u2010C\u2009\u2265130\u2009mg\/dL or on lipid\u2010lowering medications), stratified by the number of other risk factors, including smoking, diabetes, and hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We included 2667 adults, aged 75\u2009years or older (59% female), free of ASCVD; median age was 78\u2009years, with median LDL\u2010C of 117\u2009mg\/dL. In both unadjusted and adjusted analyses, there was no association between LDL\u2010C and ASCVD (adjusted hazard ratio = 1.022; 95% confidence interval = 0.998\u20101.046;\n                      <jats:italic>P<\/jats:italic>\n                      = .07). Among adults without other risk factors (free of smoking, diabetes, and hypertension), event rates were similar between those with and without hyperlipidemia (Kaplan\u2010Meier rates = 5.8% and 7.0%, respectively). Among adults with one or two or more other risk factors, the presence of hyperlipidemia was also not associated with 5\u2010year CVD event rates (Kaplan\u2010Meier rates = 12.8% vs 15.0% [\n                      <jats:italic>P<\/jats:italic>\n                      = .44] for one other risk factor and 21.9% vs 24.0% [\n                      <jats:italic>P<\/jats:italic>\n                      = .59] for two or more other risk factors).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Among a well\u2010characterized cohort, LDL\u2010C was not associated with CVD risk among adults aged 75\u2009years or older, even in the presence of other risk factors.\n                      <jats:bold>J Am Geriatr Soc 67:2560\u20132567, 2019<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16123","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T11:49:54Z","timestamp":1565783394000},"page":"2560-2567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The Association Between Low\u2010Density Lipoprotein Cholesterol and Incident Atherosclerotic Cardiovascular Disease in Older Adults: Results From the National Institutes of Health Pooled Cohorts"],"prefix":"10.1111","volume":"67","author":[{"given":"Michael G.","family":"Nanna","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Marie","family":"Navar","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wojdyla","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine  Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.13985"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60367-5"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61778-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-38461-y"},{"key":"e_1_2_6_7_1","article-title":"Ten\u2010year survival in 75\u2010year\u2010old men and women: predictive ability of total cholesterol, HDL\u2010C, and LDL\u2010C","volume":"158425","author":"Nilsson G","year":"2009","journal-title":"Curr Gerontol Geriatr Res"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00492.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.12.4.416"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1993.00410090025004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.13.1549"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010401"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.003"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.02.014"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11600-X"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-8-201004200-00005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034583"},{"key":"e_1_2_6_18_1","unstructured":"RobertsAW OgunwoleSU BlakesleeL RabeMA. 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