{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:53:06Z","timestamp":1791046386676,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["2R01AG020629"],"award-info":[{"award-number":["2R01AG020629"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG024827"],"award-info":[{"award-number":["P30 AG024827"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG050892"],"award-info":[{"award-number":["R21AG050892"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["UL1 TR001857"],"award-info":[{"award-number":["UL1 TR001857"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2019,12]]},"abstract":"\n OBJECTIVES<\/jats:title>\n Insomnia, especially difficulty maintaining sleep, is prevalent among older adults and increases the incidence of falls and fractures. Moreover, the drugs used to treat it exacerbate the risk. Yet current therapies fail to address one of its most common causes in older adults: nocturia and its primary contributor, nocturnal polyuria (NP), especially among the majority of individuals without lower urinary tract symptoms (LUTS). Therefore, we examined the factors associated with nocturia in two groups of such older women and the impact of nocturia on sleep.<\/jats:p>\n <\/jats:sec>\n \n DESIGN<\/jats:title>\n Secondary analysis of two observational studies of bladder function in carefully evaluated healthy older women.<\/jats:p>\n <\/jats:sec>\n \n SETTING<\/jats:title>\n Academic medical center.<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS<\/jats:title>\n A total of 39 women without LUTS who had adequate fluid intake (ie, >1200\u2009mL urine output\/24\u2009h recorded on their diary), normal videourodynamic testing, and normal daytime frequency (\u22647 voids).<\/jats:p>\n <\/jats:sec>\n \n MEASUREMENTS<\/jats:title>\n Voided volumes and sleep duration obtained from subjects\u2019 3\u2010day voiding diary, and sleep quality from the Center for Epidemiologic Studies Depression Scale. Nighttime excretion of more than 33% of 24\u2010hour urine volume was considered NP.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Overall, 21 of these healthy subjects (54%) awakened at least once nightly to void, and 19 (90%) of them had NP. Compared with those without nocturia, participants with nocturia had shorter duration of the first uninterrupted sleep period (182\u2009\u00b1\u2009100 vs 250\u2009\u00b1\u200960\u2009min;\n P<\/jats:italic>\n = .03), and they reported worse sleep quality. Two factors contributed independently to nocturia: (1) a larger proportion of 24\u2010hour urine output at night (43.4\u2009\u00b1\u20097.4% vs 25.4\u2009\u00b1\u20095.5%;\n P<\/jats:italic>\n = <.001) and (2) smaller bladder capacity (484\u2009\u00b1\u2009157 mL vs 608\u2009\u00b1\u2009167\u2009mL;\n P<\/jats:italic>\n = .02).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n \n Nocturia, NP, and reduced bladder capacity are very common even in healthy older women without LUTS and are associated with impaired sleep. Thus applying currently available modalities to address\n both<\/jats:italic>\n NP\n and<\/jats:italic>\n reduced bladder capacity may effectively treat sleep disruption without incurring the complications of sedative\u2010hypnotics.\n J Am Geriatr Soc 67:2610\u20132614, 2019<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.16144","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T12:32:13Z","timestamp":1566477133000},"page":"2610-2614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nocturnal Excretion in Healthy Older Women and Rationale for a Safer Approach to Sleep Disruption"],"prefix":"10.1111","volume":"67","author":[{"given":"Shachi","family":"Tyagi","sequence":"first","affiliation":[{"name":"Division of Geriatrics and Gerontology, Department of Medicine School of Medicine, University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subashan","family":"Perera","sequence":"additional","affiliation":[{"name":"Division of Geriatrics and Gerontology, Department of Medicine School of Medicine, University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Becky D.","family":"Clarkson","sequence":"additional","affiliation":[{"name":"Division of Geriatrics and Gerontology, Department of Medicine School of Medicine, University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stasa D.","family":"Tadic","sequence":"additional","affiliation":[{"name":"Division of Geriatrics and Gerontology, Department of Medicine School of Medicine, University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M.","family":"Resnick","sequence":"additional","affiliation":[{"name":"Division of Geriatrics and 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