{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:32:58Z","timestamp":1775575978559,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,22]],"date-time":"2019-12-22T00:00:00Z","timestamp":1576972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["3U01AG022376\u201005A2S"],"award-info":[{"award-number":["3U01AG022376\u201005A2S"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32 AG000181"],"award-info":[{"award-number":["T32 AG000181"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG022376"],"award-info":[{"award-number":["U01 AG022376"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Our aim was to examine the impacts of baseline fatigue on the effectiveness of a physical activity (PA) intervention to prevent major mobility disability (MMD) and persistent major mobility disability (PMMD) in participants from the Lifestyle Interventions and Independence for Elders (LIFE) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>Prospective cohort of individuals aged 65\u2009years or older undergoing structured PA intervention or health education (HE) for a mean of 2.6\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>LIFE was a multicenter eight\u2010site randomized trial that compared the efficacy of a structured PA intervention with an HE program in reducing the incidence of MMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>Study participants (N\u2009=\u20091591) at baseline were 78.9\u2009\u00b1\u20095.2\u2009years of age, with low PA and at risk for mobility impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS<\/jats:title>\n                    <jats:p>Self\u2010reported fatigue was assessed using the modified trait version of the Exercise\u2010Induced Feelings Inventory, a six\u2010question scale rating energy levels in the past week. Responses ranged from 0 (none of the time) to 5 (all of the time). Total score was calculated by averaging across questions; baseline fatigue was based on the median split: 2 or higher\u2009=\u2009more fatigue (N\u2009=\u2009856) and lower than 2\u2009=\u2009less fatigue (N\u2009=\u2009735). Participants performed a usual\u2010paced 400\u2010m walk every 6\u2009months. We defined incident MMD as the inability to walk 400\u2010m at follow\u2010up visits; PMMD was defined as two consecutive walk failures. Cox proportional hazard models quantified the risk of MMD and PMMD in PA vs HE stratified by baseline fatigue adjusted for covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Among those with higher baseline fatigue, PA participants had a 29% and 40% lower risk of MMD and PMMD, respectively, over the trial compared with HE (hazard ratio [HR] for MMD\u2009=\u2009.71; 95% confidence interval [CI] =\u2009.57\u2010.90;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.004) and PMMD (HR\u2009=\u2009.60; 95% CI\u2009=\u2009.44\u2010.82;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001). For those with lower baseline fatigue, no group differences in MMD (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.36) or PMMD (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.82) were found. Results of baseline fatigue by intervention interaction was MMD (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.18) and PMMD (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      A long\u2010term moderate intensity PA intervention was particularly effective at preserving mobility in older adults with higher levels of baseline fatigue.\n                      <jats:bold>J Am Geriatr Soc 68:619\u2013624, 2020<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16274","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T02:01:30Z","timestamp":1577066490000},"page":"619-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2265-0162","authenticated-orcid":false,"given":"Nancy W.","family":"Glynn","sequence":"first","affiliation":[{"name":"Center for Aging and Population Health, Department of Epidemiology, Graduate School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Gmelin","sequence":"additional","affiliation":[{"name":"Center for Aging and Population Health, Department of Epidemiology, Graduate School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam J.","family":"Santanasto","sequence":"additional","affiliation":[{"name":"Center for Aging and Population Health, Department of Epidemiology, Graduate School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura C.","family":"Lovato","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences Wake Forest University School of Medicine  Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittney S.","family":"Lange\u2010Maia","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Center for Community Health Equity Rush University Medical Center  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara J.","family":"Nicklas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Sticht Center on Aging Wake Forest School of Medicine  Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger A.","family":"Fielding","sequence":"additional","affiliation":[{"name":"Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd M.","family":"Manini","sequence":"additional","affiliation":[{"name":"Institute on Aging, Department of Aging and Geriatric Research University of Florida  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie H.","family":"Myers","sequence":"additional","affiliation":[{"name":"Klein Buendel, Inc  Golden Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"de Rekeneire","sequence":"additional","affiliation":[{"name":"Centre Muraz  Bobo\u2010Dioulasso Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie J.","family":"Spring","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Pahor","sequence":"additional","affiliation":[{"name":"Institute on Aging, Department of Aging and Geriatric Research University of Florida  Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abby C.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Health Research &amp; Policy, and the Stanford Prevention Research Center, Department of Medicine Stanford University School of Medicine  Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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