{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:05:16Z","timestamp":1777637116226,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Although elevated lipid levels predict increased risk of coronary heart disease and death in middle\u2010aged women and men, evidence is mixed if lipid levels measured in later life predict survival to very old ages. We examined lipid levels and survival to age 90 with or without intact mobility in a large cohort of older women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>Prospective cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>Laboratory collection at a Women's Health Initiative (WHI) center and longitudinal follow\u2010up via mail.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>Women aged 68 to 81\u2009years at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS<\/jats:title>\n                    <jats:p>Serum high\u2010density lipoprotein (HDL) and low\u2010density lipoprotein (LDL) cholesterol were collected at baseline. Participant survival status and self\u2010reported mobility was compared across lipid levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      HDL and LDL levels were not associated with survival to age 90 after adjustment for cardiovascular risk factors (HDL: quartile (Q) 2: odds ratio [OR] = 1.14 [95% confidence interval [CI] = .94\u20101.38]; Q3 OR = 1.08 [95% CI = .88\u20101.33]; Q4 OR = 1.09 [95% CI = .88\u20101.35]; LDL: Q2 OR = 1.07 [95% CI = .88\u20101.31]; Q3 OR = 1.27 [95% CI = 1.04\u20101.55]; Q4 OR = 1.07 [95% CI = .88\u20101.31]). Similarly, no associations were observed between HDL and LDL levels and survival to age 90 with mobility disability. High HDL was not associated with survival to age 90 with intact mobility after adjustment for other cardiovascular risk factors. Compared with the lowest LDL quartile, the three upper LDL quartiles were associated with greater odds of survival to age 90 with intact mobility (LDL: Q2 OR = 1.31 [95% CI = .99\u20101.74]; Q3 OR = 1.43 [95% CI = 1.07\u20101.92]; Q4 OR = 1.35 [95% CI = 1.01\u20101.80];\n                      <jats:italic>P<\/jats:italic>\n                      = .05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>\n                      Neither higher HDL nor lower LDL levels predicted survival to age 90, but higher LDL predicted healthy survival. These findings suggest the need for reevaluation of healthy LDL levels in older women.\n                      <jats:bold>J Am Geriatr Soc 68:288\u2013296, 2020<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16306","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T06:05:27Z","timestamp":1578895527000},"page":"288-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Associations between Serum Levels of Cholesterol and Survival to Age 90 in Postmenopausal Women"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4517-1623","authenticated-orcid":false,"given":"Adam X.","family":"Maihofer","sequence":"first","affiliation":[{"name":"Department of Family Medicine and Public Health School of Medicine, University of California San Diego  La Jolla California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aladdin H.","family":"Shadyab","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Public Health School of Medicine, University of California San Diego  La Jolla California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Wild","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Oklahoma Health Sciences Center  Oklahoma City Oklahoma"},{"name":"Department of Biostatistics and Epidemiology University of Oklahoma Health Sciences Center  Oklahoma City Oklahoma"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Z.","family":"LaCroix","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Public Health School of Medicine, University of California San Diego  La Jolla California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60367-5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa064278"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1993.00410090025004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/02813432.2013.824157"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010401"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/63.6.619"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01608.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-6-282"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.7.736"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-010-9154-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00465.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.77"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.19.2343"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.111.963850"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.12.015"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(97)00078-0"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00043-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00048-6"},{"key":"e_1_2_6_20_1","unstructured":"WareJE KosinskiM. 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