{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:01:36Z","timestamp":1783591296335,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T00:00:00Z","timestamp":1577664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001607","name":"Eye and Ear Foundation of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG024827"],"award-info":[{"award-number":["P30 AG024827"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG031118"],"award-info":[{"award-number":["R01 AG031118"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32 AG021885"],"award-info":[{"award-number":["T32 AG021885"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["P30 DC005205"],"award-info":[{"award-number":["P30 DC005205"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND\/OBJECTIVES<\/jats:title>\n                    <jats:p>Neuroimaging indicators of reduced brain health in the form of lower gray matter volume (GMV), lower fractional anisotropy (FA), and higher white matter hyperintensity volume (WMHV) have been related to global mobility measures, such as gait speed, in older adults. The purpose was to identify associations between brain regions and specific mobility functions to provide a greater understanding of the contribution of the central nervous system to independent living.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>Cross\u2010sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>Research laboratory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>Seventy community\u2010ambulating healthy older adults (mean age = 76\u2009\u00b1\u20095\u2009years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS<\/jats:title>\n                    <jats:p>Participants performed the following tests: gait speed, Five Times Sit to Stand, Four Square Step Test (FSST), and Dynamic Gait Index (DGI). Structural magnetic resonance imaging of each participant\u02bcs brain was collected. Measures of regional GMV, tract\u2010specific WMHV, and FA were extracted. Correlational analyses between the mobility measures and neuroimaging measures were conducted using whole brain and regional and tract\u2010specific measures. This was followed by linear regression models relating the mobility measures to regions or tracts identified in the correlation analysis, and adjusting for age, sex, and body mass index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Significant associations were found between higher GMV in multiple regions, primarily the parietal and temporal lobes, and better performance in gait speed, DGI, and FSST. After adjusting for personal factors, greater parahippocampus GMV was independently associated with greater gait speed. Greater inferior parietal lobe, supramarginal gyrus, and superior temporal gyrus GMVs were associated with gait function. Greater postcentral gyrus, parahippocampus, and superior temporal gyrus GMVs were associated with faster FSST performance. The WMHV and FA were not significantly correlated with the mobility measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      Gray matter regions associated with higher performance in mobility measures serving gait function and multidirectional stepping were those structures related to vestibular sensation, spatial navigation, and somatosensation.\n                      <jats:bold>J Am Geriatr Soc 68:1023\u20131028, 2020<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16309","type":"journal-article","created":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T01:26:10Z","timestamp":1577755570000},"page":"1023-1028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Gray Matter Regions Associated With Functional Mobility in Community\u2010Dwelling Older Adults"],"prefix":"10.1111","volume":"68","author":[{"given":"Nikki L.","family":"DiSalvio","sequence":"first","affiliation":[{"name":"Department of Physical Therapy University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Rosano","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Aizenstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Redfern","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Furman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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