{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T04:36:00Z","timestamp":1768278960910,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES<\/jats:title>\n                    <jats:p>Much of the research previously done on diabetic ketoacidosis (DKA) was based on a young population with type 1 diabetes mellitus (type 1 DM). But substantial numbers of DKA episodes occur in patients with a prior history of type 2 diabetes mellitus (type 2 DM). There is a lack of Data are lacking about DKA in older adults. The aims of this study were to analyze the clinical characteristics and outcomes of older adult patients with DKA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>Retrospective matched cohort study of adult patients hospitalized with DKA between 2004 and 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>Soroka University Medical Center, Be'er Sheva, Israel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>The clinical characteristics of DKA patients 65 years and older were compared with patients younger than 65 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS<\/jats:title>\n                    <jats:p>The primary outcome was in\u2010hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The study cohort included 385 consecutive patients for whom the admission diagnosis was DKA: 307 patients (79.7%) younger than 65 years (group 1), and 78 patients (20.3%) older than 65 years (group 2). Patients in group 2 compared with group 1 had a significantly higher Charlson index (6 [6\u20136] vs 6 [6\u20137];\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001) and DM with target organ damage (24.4% vs 6.2%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .0001). Patients in group 2 compared with group 1 had more serious disease according to results of laboratory investigations. The total in\u2010hospital mortality rate of patients in group 2 was 16.7% compared with 1.6% in patients in group 1 in a sex and co\u2010morbidities matched analysis (\n                      <jats:italic>P<\/jats:italic>\n                      = .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>DKA in older adults is a common problem. The serious co\u2010morbidities and precipitating factors such as infection\/sepsis, myocardial infarction, and cerebrovascular accidents, may explain the severity of the problem of DKA in older adults and the high rate of mortality of these patients. DKA appears to be a lifethreatening condition in older adults. The alertness of physicians to DKA in older adults, timely diagnosis, proper treatment, and prevention are cornerstones of care. J Am Geriatr Soc 68:1256\u20131261, 2020.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16376","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T06:04:17Z","timestamp":1583388257000},"page":"1256-1261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Clinical and Epidemiological Characteristics of Diabetic Ketoacidosis in Older Adults"],"prefix":"10.1111","volume":"68","author":[{"given":"Dan","family":"Schwarzfuchs","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Soroka University Medical Center  Be'er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Rabaev","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine F Soroka University Medical Center  Be'er Sheva Israel"},{"name":"Beit Yona Home for Senior Citizens  Be'er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iftach","family":"Sagy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine F Soroka University Medical Center  Be'er Sheva Israel"},{"name":"Clinical Research Center Soroka University Medical Center  Be'er Sheva Israel"},{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Be'er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noa","family":"Zimhony\u2010Nissim","sequence":"additional","affiliation":[{"name":"Clinical Research Center Soroka University Medical Center  Be'er Sheva Israel"},{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Be'er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Lipnitzki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine F Soroka University Medical Center  Be'er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadeel","family":"Musa","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Be'er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Jotkowitz","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Be'er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenia","family":"Brandstaetter","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine F Soroka University Medical Center  Be'er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2433-3240","authenticated-orcid":false,"given":"Leonid","family":"Barski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine F Soroka University Medical Center  Be'er Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00024677-200302020-00003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31827424ab"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1047"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1575-0922(09)73522-3"},{"issue":"5","key":"e_1_2_7_6_1","first-page":"S265","article-title":"California Healthcare Foundation\/American Geriatrics Society Panel on Improving Care for Elders with Diabetes. 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