{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:16:22Z","timestamp":1788477382879,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University Hospital Basel"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2020,5]]},"abstract":"\n BACKGROUND\/OBJECTIVES<\/jats:title>\n To determine the prevalence and severity of traumatic intracranial hemorrhage (tICH) in a large cohort of older adults presenting with low\u2010energy falls and the association with anticoagulation or antiplatelet medication.<\/jats:p>\n <\/jats:sec>\n \n DESIGN<\/jats:title>\n Bicentric retrospective cohort analysis.<\/jats:p>\n <\/jats:sec>\n \n SETTING<\/jats:title>\n Two level 1 trauma centers in Switzerland and Germany.<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS<\/jats:title>\n Consecutive sample of older adults (aged \u226565\u2009y) presenting to the emergency department (ED) over a 1\u2010year period with low\u2010energy falls who received cranial computed tomography (cCT) within 48\u2009hours of ED presentation.<\/jats:p>\n <\/jats:sec>\n \n MEASUREMENTS<\/jats:title>\n The prevalence and severity of tICHs was assessed and the outcomes (in\u2010hospital mortality, admission to intensive care unit [ICU], or neurosurgical intervention) were specified. We used multivariate regression models to measure the association between anticoagulation\/antiplatelet therapy and the risk for tICH after adjustment for known predictors.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n The overall prevalence for tICH detected by cCT was 176 of 2567 (6.9%). Neurosurgical intervention was performed in 15 of 176 (8.5%) patients with tICH, 28 of 176 (15.9%) patients were admitted to the ICU, and 14 of 176 (8.0%) died in the hospital. CT\u2010detected skull fracture and signs of injury above the clavicles were the strongest predictors for the presence of tICH (odds ratio [OR] = 4.28; 95% confidence interval [CI] = 2.79\u20106.51; OR = 1.88; 95% CI = 1.3\u20102.73, respectively). Among 2567 included patients, 1424 (55%) were on anticoagulation\/antiplatelet therapy. Multivariate regression models showed no differences for the risk of tICH (OR = 1.05; 95% CI =\u2009.76\u20101.47;\n P<\/jats:italic>\n =\u2009.76) or association with the head\u2010specific Injury Severity Scale (incident rate ratio = 1.08; 95% CI =\u2009.97\u20101.19;\n P<\/jats:italic>\n =\u2009.15) with or without anticoagulation\/antiplatelet therapy.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n Medication with anticoagulants or antiplatelet agents was not associated with higher prevalence and severity of tICH in older patients with low\u2010energy falls undergoing cCT examination. In addition to cCT\u2010detected skull fractures, visible injuries above the clavicles were the strongest clinical predictors for tICH. Our findings merit prospective validation.\n J Am Geriatr Soc 68:977\u2013982, 2020<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.16400","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T10:01:01Z","timestamp":1583488861000},"page":"977-982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Prevalence and Severity of Traumatic Intracranial Hemorrhage in Older Adults with Low\u2010Energy Falls"],"prefix":"10.1111","volume":"68","author":[{"given":"Alina","family":"Lampart","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Kuster","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian H.","family":"Nickel","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Bingisser","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0542-5684","authenticated-orcid":false,"given":"Vera","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University Hospital Basel Basel Switzerland"},{"name":"Department for General, Trauma and Reconstructive Surgery Ludwig Maximilian University Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.12.034"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181efc6c6"},{"key":"e_1_2_6_4_1","volume-title":"Major trauma in older people","author":"Trauma Audit and Research Network (TARN)","year":"2017"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04561-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007133430204"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-6-200703200-00004"},{"key":"e_1_2_6_8_1","volume-title":"Head Injury: Assessment and Early Management","author":"National Institute for Health and and Care Excellence (NICE)","year":"2014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1599239"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182701885"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/acem.13217"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481408001014"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.05.060"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2014.04.051"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5232"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15915"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040296"},{"key":"e_1_2_6_18_1","unstructured":"World Health Organization (WHO).International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD\u201010). 2016.http:\/\/icd.who.int\/browse10\/2016\/en. 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