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      <jats:p>\n                      Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut\u2010points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC\u2010identified metrics of low grip strength (absolute or standardized to body size\/composition); low dual\u2010energy x\u2010ray absorptiometry (DXA) lean mass as previously defined in the literature (appendicular lean mass [ALM]\/ht\n                      <jats:sup>2<\/jats:sup>\n                      ); and slowness (walking speed &lt;.8 m\/s) with subsequent adverse outcomes (falls, hip fractures, mobility limitation, and mortality).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>Individual\u2010level, sex\u2010stratified pooled analysis. We calculated odds ratios (ORs) or hazard ratios (HRs) for incident falls, mobility limitation, hip fractures, and mortality. Follow\u2010up time ranged from 1 year for falls to 8.8\u2009\u00b1\u20092.3\u2009years for mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>Eight prospective observational cohort studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>A total of 13,421 community\u2010dwelling men and 4,828 community\u2010dwelling women.<\/jats:p>\n                    <jats:p>MEASUREMENTS<\/jats:p>\n                    <jats:p>Grip strength by hand dynamometry, gait speed, and lean mass by DXA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Low grip strength (absolute or standardized to body size\/composition) was associated with incident outcomes, usually independently of slowness, in both men and women. ORs and HRs generally ranged from 1.2 to 3.0 for those below vs above the cut\u2010point. DXA lean mass was not consistently associated with these outcomes. When considered together, those who had both muscle weakness by absolute grip strength (&lt;35.5 kg in men and &lt;20\u2009kg in women) and slowness were consistently more likely to have a fall, hip fracture, mobility limitation, or die than those without either slowness or muscle weakness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Older men and women with both muscle weakness and slowness have a higher likelihood of adverse health outcomes. These results support the inclusion of grip strength and walking speed as components in a summary definition of sarcopenia. J Am Geriatr Soc 68:1429\u20101437, 2020.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16517","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T09:16:06Z","timestamp":1594113366000},"page":"1429-1437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":219,"title":["Putative Cut\u2010Points in Sarcopenia Components and Incident Adverse Health Outcomes: An\n                    <scp>SDOC<\/scp>\n                    Analysis"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4938-9478","authenticated-orcid":false,"given":"Peggy M.","family":"Cawthon","sequence":"first","affiliation":[{"name":"Research Institute California Pacific Medical Center  San Francisco California"},{"name":"Department of Epidemiology and Biostatistics University of California San Francisco  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Manini","sequence":"additional","affiliation":[{"name":"University of Florida  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheena M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Research Institute California Pacific Medical Center  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Travison","sequence":"additional","affiliation":[{"name":"Marcus Institute for Aging Research Hebrew SeniorLife, Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas P.","family":"Kiel","sequence":"additional","affiliation":[{"name":"Marcus Institute for Aging Research Hebrew SeniorLife, Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Santanasto","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9069-3036","authenticated-orcid":false,"given":"Kristine E.","family":"Ensrud","sequence":"additional","affiliation":[{"name":"Center for Chronic Disease Outcomes Research Minneapolis VA Health Care System  Minneapolis Minnesota"},{"name":"Division of Epidemiology and Community Health University of Minnesota  Minneapolis Minnesota"},{"name":"Department of Medicine University of Minnesota  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian\u2010Li","family":"Xue","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine and Gerontology and Center on Aging and Health Johns Hopkins Medical Institute  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Shardell","sequence":"additional","affiliation":[{"name":"Longitudinal Studies Section The National Institute on Aging  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Duchowny","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California San Francisco  San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine M.","family":"Erlandson","sequence":"additional","affiliation":[{"name":"University of Colorado Denver\u2010Anschutz Medical Campus  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol M.","family":"Pencina","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Pittsburgh  Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Fielding","sequence":"additional","affiliation":[{"name":"Nutrition, Exercise, Physiology, and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging Tufts University  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Magaziner","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health University of Maryland School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Kwok","sequence":"additional","affiliation":[{"name":"Department of Medicine &amp; 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