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In baseline and follow\u2010up visits, patients underwent magnetic resonance imaging and ABPM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS<\/jats:title>\n                    <jats:p>Ambulatory systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels were studied as continuous variables and dichotomized according to good or poor control on the basis of 125\/75 (24\u2009hours), 130\/80 (day), and 110\/65 (night) mm Hg cutoff values. Whole cSVD progression was qualitatively scored with 1 point when an incident lesion (incident lacunar infarcts, deep cerebral microbleeds, white matter hyperintensities, and basal ganglia enlarged perivascular spaces) was detected. The score ranged from 0 to 4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We followed up 233 participants with a median age of 65\u2009years within 4\u2009years. A total of 61 (26.2%) and 23 (9.9%) subjects showed cSVD progression in one and two or more markers, respectively. Baseline ambulatory SBP and DBP and nighttime pulse pressure (PP) values were positively correlated with the number of incident cSVD lesions. Interestingly, patients without incident lesions showed greater differences between office and ambulatory BP, thus suggesting an increased white coat effect. Poor DBP control, nighttime PP, and DBP white coat effect were independently associated with cSVD progression. The inclusion of these metrics in a clinical model resulted in a significant increase in the prediction of incident lesions (integrated discrimination improvement = 9.09%;\n                      <jats:italic>P<\/jats:italic>\n                      value &lt;.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>ABPM may help assess cSVD risk of progression, especially by the identification of poor BP control, masked hypertension, and increased nighttime PP. J Am Geriatr Soc 68:2232\u20132239, 2020.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16568","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T13:01:35Z","timestamp":1591621295000},"page":"2232-2239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ambulatory Blood Pressure Levels in the Prediction of Progression of Cerebral Small Vessel Disease"],"prefix":"10.1111","volume":"68","author":[{"given":"Joan","family":"Jim\u00e9nez\u2010Balado","sequence":"first","affiliation":[{"name":"Neurovascular Research Lab, Vall Hebron Research Institute Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iolanda","family":"Riba\u2010Llena","sequence":"additional","affiliation":[{"name":"Neurovascular Research Lab, Vall Hebron Research Institute Universitat Aut\u00f2noma de Barcelona  Barcelona 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