{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:03:07Z","timestamp":1762210987986,"version":"build-2065373602"},"reference-count":60,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG051125","RF1 AG055273"],"award-info":[{"award-number":["R01 AG051125","RF1 AG055273"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND\/OBJECTIVES<\/jats:title>\n                    <jats:p>Genetic factors play an important role in Alzheimer's disease (AD) and cognitive aging. However, it is unclear whether risk loci identified in European ancestry (EA) populations have similar effects in other groups, such as South Asians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>We investigated the allelic distribution and cognitive associations of 56 known AD risk single\u2010nucleotide polymorphisms (SNPs) identified from three EA genome\u2010wide association studies (EA\u2010GWASs) in a South Asian population. Single SNP and genetic risk score (GRS) associations with measures of episodic memory were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>The Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI\u2010DAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>A total of 906 LASI\u2010DAD participants from diverse states in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS<\/jats:title>\n                    <jats:p>Participants were genotyped using the Illumina Global Screening Array and imputed with 1000G Phase 3v5. Cognitive measures included total learning and delayed word recall.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Although only a few SNPs were significantly associated with memory scores (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05), effect estimates from the EA\u2010GWAS and the LASI\u2010DAD showed moderate correlation (0.35\u20130.88) in the expected direction. GRSs were also associated with memory scores, although percentage variation explained was small (0.1%\u20130.6%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Discrepancies in allele frequencies and cognitive association results suggest that genetic factors found predominantly through EA\u2010GWASs may play a limited role in South Asians. However, the extent of differences in the genetic architecture of AD and cognition in EA and South Asians remains uncertain. There is also a critical need to perform a more comprehensive assessment of the mutational spectrum of South Asia to identify novel genetic variants associated with AD and cognition in this population. J Am Geriatr Soc 68:S45\u2010S53, 2020.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16735","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T01:57:13Z","timestamp":1598579833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association Between Episodic Memory and Genetic Risk Factors for Alzheimer's Disease in South Asians from the Longitudinal Aging Study in India\u2013Diagnostic Assessment of Dementia (LASI\u2010DAD)"],"prefix":"10.1111","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3575-5468","authenticated-orcid":false,"given":"Jennifer A.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Michigan  Ann Arbor Michigan USA"},{"name":"Survey Research Center, Institute for Social Research University of Michigan  Ann Arbor Michigan 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California  Berkeley California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ganna","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Finland  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aparajit B.","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinkook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Economics University of Southern California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon L.R.","family":"Kardia","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Michigan  Ann Arbor Michigan 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