{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T16:09:35Z","timestamp":1793117375754,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG053297"],"award-info":[{"award-number":["R01AG053297"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R56AG064952"],"award-info":[{"award-number":["R56AG064952"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND\/OBJECTIVES<\/jats:title>\n                    <jats:p>Motoric cognitive risk (MCR) syndrome is characterized by cognitive complaints and slow gait speed in the absence of dementia. Consistent evidence indicates that it predicts dementia and premature mortality. Less is known about its antecedents, particularly the role of psychological function. Purpose in life is an aspect of well\u2010being that reflects a goal\u2010oriented and \u2010driven life that has been implicated in cognitive aging. We aimed to examine the cross\u2010sectional association between purpose in life and MCR and to test the hypothesis that purpose is associated with a lower risk of new cases of MCR over an up to 12\u2010year follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>Cross\u2010sectional and longitudinal multi\u2010cohort design.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>Health and Retirement Study (HRS) and the National Health and Aging Trends Study (NHATS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>A total of 6,785 individuals from the HRS and 5,665 from the NHATS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS<\/jats:title>\n                    <jats:p>Participants reported on their purpose in life and cognitive complaints and completed a walking speed assessment. Cognitive complaints and walking speed were assessed again up to 12\u2009years later in HRS and up to 7\u2009years later in NHATS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Higher purpose in life was associated with a 33% lower risk of MCR concurrently (meta\u2010analytic odds ratio = .75; 95% confidence interval [CI] = .62\u2013.90;\n                      <jats:italic>P<\/jats:italic>\n                      =\u2009.002) and an about 26% lower risk of incident MCR longitudinally (meta\u2010analytic hazard ratio = .77; 95% CI =\u2009.70\u2013.84;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;\u2009.001). These associations were significant in each sample, were independent of sociodemographic covariates, and persisted after controlling for personality and health\u2010related factors (depressive symptoms, physical activity, disease burden).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Purpose in life is associated with a lower risk of incident MCR, an association that was replicated in two independent samples. Purpose is a malleable aspect of psychological function that is a promising target of intervention for healthier cognitive aging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16852","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T16:45:14Z","timestamp":1601484314000},"page":"381-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Purpose in Life and Motoric Cognitive Risk Syndrome: Replicable Evidence from Two National Samples"],"prefix":"10.1111","volume":"69","author":[{"given":"Angelina R.","family":"Sutin","sequence":"first","affiliation":[{"name":"Department of Behavioral Sciences and Social Medicine Florida State University College of Medicine  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Luchetti","sequence":"additional","affiliation":[{"name":"Department of Behavioral Sciences and Social Medicine Florida State University College of Medicine  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Stephan","sequence":"additional","affiliation":[{"name":"Euromov University of Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Terracciano","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Florida State University College of Medicine  Tallahassee Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317515592331"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afx084"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls191"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000717"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.08.167"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101022"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13891"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16282"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16424"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.57.6.1069"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcop.22200"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2015.09.013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.2145"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000274"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.208"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4849"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.1487"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533317513504817"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/13825585.2016.1251549"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2020.104033"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2019.01.010"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu067"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz109"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbr048"},{"key":"e_1_2_6_26_1","unstructured":"LachmanME WeaverSL.Midlife Development Inventory (MIDI) personality scales: scale construction and scoring. 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