{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T12:52:20Z","timestamp":1762174340488,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG030644"],"award-info":[{"award-number":["U01 AG030644"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND\/OBJECTIVES<\/jats:title>\n                    <jats:p>Accurate estimates of clinically important difference (CID) are required for interpreting the clinical importance of treatments to improve physical function, but CID estimates vary in different disease populations. We determined the CID for two common measures of walking ability in mobility\u2010limited older men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Longitudinal, multisite placebo\u2010controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting\/Participants<\/jats:title>\n                    <jats:p>Men enrolled in the Testosterone Trials who had self\u2010reported mobility limitation and gait speed less than 1.2 m\/second (n = 429). Testosterone\u2010 and placebo\u2010allocated participants were combined for this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Mean changes from baseline, adjusting for time\u2010in\u2010intervention and site, were 29.6, 13.2, 12.5, \u22122.4, and \u221232.6 m for 6MWD, and 15.4, 7.2, 2.1, \u22123.4, and \u22127.2 for PF10 in men who reported their mobility was \u201cvery\/much better,\u201d \u201clittle better,\u201d \u201cno change,\u201d \u201clittle worse,\u201d or \u201cmuch worse,\u201d respectively. CID estimates using regression, ROC, and eCDF varied from 5.0\u201329.6 m for 6MWD, and 5.0\u201315.2 points for PF10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>CID estimates vary by the population studied and by the method and precision of measurement. Increases of 16 to 30 m for 6MWD and 5 to 15 points for PF10 over 12 months appear to be clinically meaningful in mobility\u2010limited, older hypogonadal men. These CID estimates may be useful in the design of efficacy trials of therapies to improve physical function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16942","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T01:50:24Z","timestamp":1605750624000},"page":"517-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinically Important Differences for Mobility Measures Derived from the Testosterone Trials"],"prefix":"10.1111","volume":"69","author":[{"given":"Alisa J.","family":"Stephens\u2010Shields","sequence":"first","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Farrar","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan S.","family":"Ellenberg","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5974-9791","authenticated-orcid":false,"given":"Thomas W.","family":"Storer","sequence":"additional","affiliation":[{"name":"Research Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6450-0368","authenticated-orcid":false,"given":"Thomas M.","family":"Gill","sequence":"additional","affiliation":[{"name":"Section of Geriatric Medicine Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shehzad","family":"Basaria","sequence":"additional","affiliation":[{"name":"Research Program in Men's Health: Aging and Metabolism, Boston Claude D. 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