{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:52:51Z","timestamp":1782895971704,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["5T32DK007219\u201043"],"award-info":[{"award-number":["5T32DK007219\u201043"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["2R01AG027002"],"award-info":[{"award-number":["2R01AG027002"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background\/Objectives<\/jats:title>\n                    <jats:p>Non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) can cause kidney injury, especially in older adults. However, previously reported associations between NSAID use and kidney health outcomes are inconsistent and limited by reliance on serum creatinine\u2010based GFR estimates. This analysis investigated the association of NSAID use with kidney damage in older adults using multiple kidney health measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional and longitudinal analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Multicenter, community\u2010based cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Two thousand nine hundred and ninty nine older adults in the Health ABC Study. A subcohort (n = 500) was randomly selected for additional biomarker measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Exposure<\/jats:title>\n                    <jats:p>Prescription and over\u2010the\u2010counter NSAID use ascertained by self\u2010report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Baseline estimated glomerular filtration rate (eGFR) by cystatin C (cysC), urine albumin\u2010to\u2010creatinine ratio (ACR), kidney injury molecule\u20101 (KIM\u20101), and interleukin\u201018 (IL\u201018) were measured in 2,999 participants; alpha\u20101 microglobulin (\u03b11m), neutrophil gelatinase\u2010associated lipocalin (NGAL), propeptide type III procollagen (PIIINP), and uromodulin (UMOD) were measured in 500 participants. GFR was estimated three times over 10\u2009years and expressed as percent change per year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants had a mean age of 74\u2009years, 51% were female, and 41% African\u2010American. No eGFR differences were detected between NSAID users (n = 655) and non\u2010users (n = 2,344) at baseline (72\u2009ml\/min\/1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      in both groups). Compared to non\u2010users, NSAID users had lower adjusted odds of having ACR greater than 30\u2009mg\/g (0.67; 95% confidence interval (CI) = 0.51\u20130.89) and lower mean urine IL\u201018 concentration at baseline (\u221211%; 95% CI = \u22124% to \u221218%), but similar mean KIM\u20101 (5%; 95% CI = \u22125% to 14%). No significant differences in baseline concentrations of the remaining urine biomarkers were detected. NSAID users and non\u2010users did not differ significantly in the rate of eGFR decline (\u22122.2% vs \u20102.3% per year).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Self\u2010reported NSAID use was not associated with kidney dysfunction or injury based on multiple measures, raising the possibility of NSAID use without kidney harm in ambulatory older adults. More research is needed to define safe patterns of NSAID consumption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16961","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T01:49:43Z","timestamp":1607651383000},"page":"726-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association of Non\u2010Steroidal Anti\u2010Inflammatory Drugs with Kidney Health in Ambulatory Older Adults"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0118-7909","authenticated-orcid":false,"given":"Jonathan G.","family":"Amatruda","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of California, San Francisco  San Francisco California USA"},{"name":"Kidney Health Research Collaborative San Francisco VA Medical Center &amp; University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronit","family":"Katz","sequence":"additional","affiliation":[{"name":"Kidney Research Institute University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen A.","family":"Peralta","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of California, San Francisco  San Francisco California USA"},{"name":"Kidney Health Research Collaborative San Francisco VA Medical Center &amp; University of California, San Francisco  San Francisco California USA"},{"name":"Chief Medical Office Cricket Health, Inc.  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