{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:07:59Z","timestamp":1778134079927,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Exacerbation of or new onset orthostatic hypotension in perioperative patients can occur. There is complex underlying pathophysiology with further derailment likely caused by acute cardiovascular changes associated with surgery. The implications for post\u2010operative recovery are unclear, particularly in frail and older patients. We retrospectively explored patient notes for evidence of post\u2010operative orthostatic intolerance in relation to pre\u2010operative orthostatic hypotension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Supine and 1\u2010minute and 3\u2010minute standing blood pressure measures obtained from adult patients before mainly general, orthopedic or uro\/gynecology surgery were compared to post\u2010operative outcome, specifically, evidence in patient notes about falls, feeling dizzy\/unsteady and\/or fearful to stand. Orthostatic hypotension was defined as a 20\u2009mmHg or more and\/or 10\u2009mmHg or more fall in systolic and diastolic blood pressure, respectively, within ~3\u2009minutes of standing after lying supine for an electrocardiogram.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Whilst all patients included had a 1\u2010minute standing blood pressure assessment (N\u2009=\u2009170), 3\u2010minute assessment was performed less commonly (N\u2009=\u2009113). Nevertheless, one\u2010quarter (23.5%; N\u2009=\u200940) of 170 patients had pre\u2010operative orthostatic hypotension. This was not clearly explained by cardiac or neurological disease or by common medications, but did occur more frequently in older patients and in those aged 65\u2009years or more with higher clinical frailty scale scores. The COVID\u201019 pandemic reduced the number of patients progressing to surgery within the planned study timescale (N\u2009=\u2009143\/170; 84.1%). Nevertheless, patients with orthostatic hypotension stayed longer in hospital post\u2010operatively and were more likely to have an episode of fall, unsteadiness and\/or dizziness documented (un\u2010prompted) in their notes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>These data provide further impetus for research into modifiable perioperative risk factors associated with orthostatic hypotension. These risks are not confined to those with a pre\u2010existing dysautonomia diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16966","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T21:37:04Z","timestamp":1607722624000},"page":"767-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Effect of Orthostatic Hypotension Detected\n                    <scp>Pre\u2010Operatively<\/scp>\n                    on\n                    <scp>Post\u2010Operative<\/scp>\n                    Outcome"],"prefix":"10.1111","volume":"69","author":[{"given":"Alexandra M.","family":"Hogan","sequence":"first","affiliation":[{"name":"Anaesthetics Department &amp; Pre\u2010Operative Assessment Clinic Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust  Cambridge United Kingdom"},{"name":"Cognitive Neuroscience UCL Great Ormond Street Institute of Child Health  London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Luck","sequence":"additional","affiliation":[{"name":"Anaesthetics Department &amp; Pre\u2010Operative Assessment Clinic Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust  Cambridge United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1681-6058","authenticated-orcid":false,"given":"Sarah","family":"Woods","sequence":"additional","affiliation":[{"name":"Anaesthetics Department &amp; Pre\u2010Operative Assessment Clinic Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust  Cambridge United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ortu","sequence":"additional","affiliation":[{"name":"Anaesthetics Department &amp; Pre\u2010Operative Assessment Clinic Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust  Cambridge United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svet","family":"Petkov","sequence":"additional","affiliation":[{"name":"Anaesthetics Department &amp; Pre\u2010Operative Assessment Clinic Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust  Cambridge United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"issue":"11","key":"e_1_2_6_2_1","first-page":"1294","article-title":"Orthostatic Hypotension","volume":"72","author":"Freeman R","year":"2018","journal-title":"JACC State Art Rev JACC"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.009831"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2018.04.018"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-017-0314-y"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13238"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer403"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-020-00697-y"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050051"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-017-0409-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000072"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv093"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afr182"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-012-1391-9"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.16966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgs.16966","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.16966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T14:21:28Z","timestamp":1762179688000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.16966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,11]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/jgs.16966"],"URL":"https:\/\/doi.org\/10.1111\/jgs.16966","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,11]]},"assertion":[{"value":"2020-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}