{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T23:16:06Z","timestamp":1782515766583,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aims of this study are to report the prevalence of delirium on admission to the unit in patients hospitalized with SARS\u2010CoV\u20102 infection, to identify the factors associated with delirium, and to evaluate the association between delirium and in\u2010hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Multicenter observational cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings<\/jats:title>\n                    <jats:p>Acute medical units in four Italian hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 516 patients (median age 78\u2009years) admitted to the participating centers with SARS\u2010CoV\u20102 infection from February 22 to May 17, 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Comprehensive medical assessment with detailed history, physical examinations, functional status, laboratory and imaging procedures. On admission, delirium was determined by the Diagnostic and Statistical Manual of Mental Disorders (5th edition) criteria, 4AT, m\u2010Richmond Agitation Sedation Scale, or clinical impression depending on the site. The primary outcomes were delirium rates and in\u2010hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 73 (14.1%, 95% confidence interval (CI) = 11.0\u201317.3%) patients presented delirium on admission. Factors significantly associated with delirium were dementia (odds ratio, OR = 4.66, 95% CI = 2.03\u201310.69), the number of chronic diseases (OR = 1.20, 95% CI = 1.03; 1.40), and chest X\u2010ray or CT opacity (OR = 3.29, 95% CI = 1.12\u20139.64 and 3.35, 95% CI = 1.07\u201310.47, for multiple or bilateral opacities and single opacity vs no opacity, respectively). There were 148 (33.4%) in\u2010hospital deaths in the no\u2010delirium group and 43 (58.9%) in the delirium group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value assessed using the Gray test &lt;.001). As assessed by a multivariable Cox model, patients with delirium on admission showed an almost twofold increased hazard ratio for in\u2010hospital mortality with respect to patients without delirium (hazard ratio = 1.88, 95% CI = 1.25\u20132.83).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Delirium is prevalent and associated with in\u2010hospital mortality among older patients hospitalized with SARS\u2010CoV\u20102 infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16969","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T12:09:12Z","timestamp":1606478952000},"page":"293-299","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Delirium in Patients with\n                    <scp>SARS\u2010CoV<\/scp>\n                    \u20102 Infection: A Multicenter Study"],"prefix":"10.1111","volume":"69","author":[{"given":"Paola","family":"Rebora","sequence":"first","affiliation":[{"name":"Bicocca Center of Bioinformatics, Biostatistics and Bioimaging, School of Medicine and Surgery, University of Milano\u2010Bicocca  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Rozzini","sequence":"additional","affiliation":[{"name":"Geriatric Department Fondazione Poliambulanza Istituto Ospedaliero  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Bianchetti","sequence":"additional","affiliation":[{"name":"Medicine and Rehabilitation Department Istituto Clinico S. Anna Hospital  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Blangiardo","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milano  Bicocca, Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Marchegiani","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milano  Bicocca, Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Piazzoli","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milano  Bicocca, Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mazzeo","sequence":"additional","affiliation":[{"name":"Geriatric Department Fondazione Poliambulanza Istituto Ospedaliero  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Cesaroni","sequence":"additional","affiliation":[{"name":"Geriatric Department Fondazione Poliambulanza Istituto Ospedaliero  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Chizzoli","sequence":"additional","affiliation":[{"name":"Medicine and Rehabilitation Department Istituto Clinico S. Anna Hospital  Brescia Italy"},{"name":"Department of Clinical and Experimental Sciences Geriatric School, University of Brescia  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Guerini","sequence":"additional","affiliation":[{"name":"Medicine and Rehabilitation Department Istituto Clinico S. Anna Hospital  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bonfanti","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milano  Bicocca, Monza Italy"},{"name":"Infectious Diseases Unit, San Gerardo Hospital  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4848-2507","authenticated-orcid":false,"given":"Alessandro","family":"Morandi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Aged Care \u201cFondazione Camplani\u201d Hospital  Cremona Italy"},{"name":"Parc Sanitari Pere Virgili and Vall d'Hebr\u00f3n Institute of Research  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Faraci","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Aged Care \u201cFondazione Camplani\u201d Hospital  Cremona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Gentile","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Aged Care \u201cFondazione Camplani\u201d Hospital  Cremona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Bna","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging Fondazione Poliambulanza Istituto Ospedaliero  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giordano","family":"Savelli","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Imaging Fondazione Poliambulanza Istituto Ospedaliero  Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Citerio","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milano  Bicocca, Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Valsecchi","sequence":"additional","affiliation":[{"name":"Bicocca Center of Bioinformatics, Biostatistics and Bioimaging, School of Medicine and Surgery, University of Milano\u2010Bicocca  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Mazzola","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milano  Bicocca, Monza Italy"},{"name":"Acute Geriatric Unit, San Gerardo hospital  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5430-0947","authenticated-orcid":false,"given":"Giuseppe","family":"Bellelli","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery, University of Milano  Bicocca, Monza Italy"},{"name":"Acute Geriatric Unit, San Gerardo hospital  Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the CoViD\u201019 Lombardia Team","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111255"},{"key":"e_1_2_6_3_1","unstructured":"Epidemiology for Public Health Istituto Superiore di Sanit\u00e0. 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