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We sought to examine associations between psychotropic medication exposure and longitudinal change in cognitive, functional, and neuropsychiatric outcomes in a large clinical AD cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>Longitudinal observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>National Alzheimer's Disease Coordinating Center combining data from 39 Alzheimer's disease centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS<\/jats:title>\n                    <jats:p>8,034 participants with AD dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MEASUREMENTS<\/jats:title>\n                    <jats:p>Mini\u2010Mental State Exam (MMSE), Clinical Dementia Rating Scale\u2010Sum of Boxes (CDR\u2010SB), and Neuropsychiatric Inventory Questionnaire (NPI\u2010Q) Total. Probability of exposure to medication (the propensity score, PS) calculated via logistic regression. Medication classes included all antipsychotics (atypical vs conventional), antidepressants (Selective Serotonin Reuptake Inhibitor [SSRI] vs non\u2010SSRI), and benzodiazepines. Participants treated with a medication class were matched with participants not treated with that class with the closest\u2010matched PS. The effect of medication treatment was assessed using linear mixed\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Participants had a mean (SD) age of 75.5 (9.8) years, and mean (SD) scores of MMSE 21.3 (5.7), CDR\u2010SB 5.5 (3.4), and NPI\u2010Q Total 4.5 (4.4). Mean duration of follow\u2010up was 2.9\u20133.3\u2009years depending on medication class. Non\u2010SSRI antidepressant use was associated with better CDR\u2010SB (2\u2010year difference in change\u2010DIC: \u22120.38 [\u22120.61, \u22120.15],\n                      <jats:italic>P<\/jats:italic>\n                      = .001). Atypical antipsychotic use was associated with greater decline on MMSE (DIC: \u22120.91 [\u22121.54, \u22120.28]\n                      <jats:italic>P<\/jats:italic>\n                      = .005) and CDR\u2010SB scores (DIC: 0.50 [0.14, 0.86],\n                      <jats:italic>P<\/jats:italic>\n                      = .006). Notably, no drug class was associated with better NPI\u2010Q scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Use of atypical antipsychotics was associated with poorer cognition and function, and no drug class was associated with improvement in neuropsychiatric symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.16970","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T17:44:37Z","timestamp":1609436677000},"page":"955-963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Psychotropic Medication and Cognitive, Functional, and Neuropsychiatric Outcomes in Alzheimer's Disease (AD)"],"prefix":"10.1111","volume":"69","author":[{"given":"Esther S.","family":"Oh","sequence":"first","affiliation":[{"name":"Department of 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