{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:58:04Z","timestamp":1790873884124,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2021,5]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n To examine age\u2010related trajectories of cardiovascular risk and use of aspirin and statin among U.S. adults aged 50 or older.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Repeated cross\u2010sectional study using data from 2011 to 2018 National Health and Nutrition Examination Surveys.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Nationally representative health interview survey in the United States.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Non\u2010institutionalized adults aged 50\u2009years and older (\n n<\/jats:italic>\n \u00a0=\u00a011,392 unweighted).\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n Primary prevention was defined as the prevention of a first cardiovascular event including coronary heart disease, angina\/angina pectoris, heart attack, or stroke, whereas secondary prevention was defined as those with a history of these clinical conditions. Medication use was determined by self\u2010report; aspirin use included dose and frequency, and statin use included generic names, days of prescription fills, and indications. We examined linear trends between age and each medication use, after controlling for period, sex, and race\/ethnicity.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Prevalence of those eligible for primary prevention treatment increased with age from 31.8% in ages 50\u201354 to 52.0% in ages \u226575 (\n p<\/jats:italic>\n \u2009<\u20090.001). Similarly, those eligible for secondary prevention treatment increased with age from 2.7% in ages 50\u201354 to 21.1% in ages \u226575 (\n p<\/jats:italic>\n \u2009<\u20090.001). Low\u2010dose daily aspirin use increased with age (\n p<\/jats:italic>\n \u2009<\u20090.001), and 45.3% of adults aged \u226575 took low\u2010dose aspirin daily for primary prevention. Statin use also increased with age (\n p<\/jats:italic>\n \u2009<\u20090.001), and 56.4% of adults aged \u226575 had long\u2010term statin use for secondary prevention.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n While adults aged \u226575 do not benefit from the use of aspirin to prevent the first CVD, many continue to take aspirin on a regular basis. In spite of the clear benefit of statin use to prevent a subsequent CVD event, many older adults in this risk category are not taking a statin. Further education and guidance for both healthcare providers and older adults regarding the appropriate use of aspirin and statins to prevent CVD is needed.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.17038","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T10:51:18Z","timestamp":1613818278000},"page":"1272-1282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Age\u2010Related Trajectories of Cardiovascular Risk and Use of Aspirin and Statin Among\n U.S.<\/scp>\n Adults Aged 50 or Older, 2011\u20132018"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4961-3361","authenticated-orcid":false,"given":"Taeho Greg","family":"Rhee","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences University of Connecticut School of Medicine Farmington Connecticut USA"},{"name":"Department of Psychiatry Yale School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Pat and Jim Calhoun Cardiology Center University of Connecticut Health Farmington Connecticut USA"},{"name":"Department of Internal Medicine University of Connecticut School of Medicine Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Ross","sequence":"additional","affiliation":[{"name":"Section of General Internal Medicine Yale School of Medicine New Haven Connecticut USA"},{"name":"Yale Center for Outcomes Research and Evaluation (CORE), Yale\u2010New Haven Health System New Haven Connecticut USA"},{"name":"Department of Health Policy and Management Yale School of Public Health New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick P.","family":"Coll","sequence":"additional","affiliation":[{"name":"Center on Aging University of Connecticut Health Farmington Connecticut USA"},{"name":"Department of Family Medicine University of Connecticut School of Medicine Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"issue":"7","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41584-020-0428-y","article-title":"Atherosclerotic cardiovascular disease prevention in rheumatoid arthritis","volume":"16","author":"Semb AG","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"e_1_2_7_3_1","unstructured":"World Health Organization.Cardiovascular diseases 2020.https:\/\/www.who.int\/health-topics\/cardiovascular-diseases\/#tab=tab_1. 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