{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:53:20Z","timestamp":1785545600968,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/objectives<\/jats:title>\n                    <jats:p>Limited knowledge exists regarding sex differences in prescribing potentially inappropriate medications (PIMs) for various multimorbidity patterns. This study sought to determine sex differences in PIM prescribing in older adults with cardiovascular\u2010metabolic patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Health and Retirement Study (HRS) 2004\u20132014 interview data, linked to HRS\u2010Medicare claims data annualized for 2005\u20132014.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study sample<\/jats:title>\n                    <jats:p>Six thousand three\u2010hundred and forty\u2010one HRS participants aged 65 and older with two and more chronic conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>PIM events were calculated using 2015 American Geriatrics Society Beers Criteria. Multimorbidity patterns included: \u201ccardiovascular\u2010metabolic only,\u201d \u201ccardiovascular\u2010metabolic plus other physical conditions,\u201d \u201ccardiovascular\u2010metabolic plus mental conditions,\u201d and \u201cno cardiovascular\u2010metabolic disease\u201d patterns. Logistic regression models were used to determine the association between PIM and sex, including interaction between sex and multimorbidity categories in the model, for PIM overall and for each PIM drug class.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Women were prescribed PIMs more often than men (39.4% vs 32.8%). Overall, women had increased odds of PIM (Adj. odds ratio [OR]\u00a0=\u00a01.30, 95% confidence interval [CI]: 1.16\u20131.46). Women had higher odds of PIM than men with cardiovascular\u2010metabolic plus physical patterns (Adj. OR\u00a0=\u00a01.25, 95% CI: 1.07\u20131.45) and cardiovascular\u2010metabolic plus mental patterns (Adj. OR\u00a0=\u00a01.25, 95% CI: 1.06\u20131.48), and there were no sex differences in adults with a cardiovascular\u2010metabolic only patterns (Adj. OR\u00a0=\u00a01.13, 95% CI: 0.79\u20131.62). Women had greater odds of being prescribed the following PIMs: anticholinergics, antidepressants, antispasmodics, benzodiazepines, skeletal muscle relaxants, and had lower odds of being prescribed pain drugs and sulfonylureas compared with men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study evaluated sex differences in PIM prescribing among adults with complex cardiovascular\u2010metabolic multimorbidity patterns. The effect of sex varied across multimorbidity patterns and by different PIM drug classes. This study identified important opportunities for future interventions to improve medication prescribing among older adults at risk for PIM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.17194","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T10:12:28Z","timestamp":1620468748000},"page":"2163-2175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Are there sex differences in potentially inappropriate prescribing in adults with multimorbidity?"],"prefix":"10.1111","volume":"69","author":[{"given":"Maria","family":"Ukhanova","sequence":"first","affiliation":[{"name":"Department of Family Medicine Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Markwardt","sequence":"additional","affiliation":[{"name":"School of Public Health Oregon Health &amp; Science University  Portland 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