{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:56:42Z","timestamp":1790643402265,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012619","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Fragilidad y Envejecimiento Saludable","doi-asserted-by":"publisher","award":["CB16\/10\/00408"],"award-info":[{"award-number":["CB16\/10\/00408"]}],"id":[{"id":"10.13039\/100012619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["COV20\/00004"],"award-info":[{"award-number":["COV20\/00004"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Older adults are at the highest risk of severe disease and death due to COVID\u201019. Randomized data have shown that baricitinib improves outcomes in these patients, but focused stratified analyses of geriatric cohorts are lacking. Our objective was to analyze the efficacy of baricitinib in older adults with COVID\u201019 moderate\u2010to\u2010severe pneumonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a propensity score [PS]\u2010matched retrospective cohort study. Patients from the COVID\u2010AGE and Alba\u2010Score cohorts, hospitalized for moderate\u2010to\u2010severe COVID\u201019 pneumonia, were categorized in two age brackets of age &lt;70\u2009years old (86 with baricitinib and 86 PS\u2010matched controls) or \u226570\u2009years old (78 on baricitinib and 78 PS\u2010matched controls). Thirty\u2010day mortality rates were analyzed with Kaplan\u2013Meier and Cox proportional hazard models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean age was 79.1 for those \u226570\u2009years and 58.9 for those &lt;70. Exactly 29.6% were female. Treatment with baricitinib resulted in a significant reduction in death from any cause by 48% in patients aged 70 or older, an 18.5% reduction in 30\u2010day absolute mortality risk (n\/N: 16\/78 [20.5%] baricitinib, 30\/78 [38.5%] in PS\u2010matched controls,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a lower 30\u2010day adjusted fatality rate (HR 0.21; 95% CI 0.09\u20130.47;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Beneficial effects on mortality were also observed in the age group &lt;70 (8.1% reduction in 30\u2010day absolute mortality risk; HR 0.14; 95% CI 0.03\u20130.64;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Baricitinib is associated with an absolute mortality risk reduction of 18.5% in adults older than 70\u2009years hospitalized with COVID\u201019 pneumonia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.17357","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T03:06:12Z","timestamp":1625713572000},"page":"2752-2758","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Baricitinib reduces 30\u2010day mortality in older adults with moderate\u2010to\u2010severe\n                    <scp>COVID<\/scp>\n                    \u201019 pneumonia"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4707-2963","authenticated-orcid":false,"given":"Pedro","family":"Abizanda","sequence":"first","affiliation":[{"name":"Department of Geriatrics Complejo Hospitalario Universitario de Albacete  Albacete Spain"},{"name":"CIBERFES Ministerio de Econom\u00eda y Competitividad  Madrid Spain"},{"name":"Facultad de Medicina Universidad de Castilla\u2010La Mancha  Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Mar\u00eda","family":"Calbo Mayo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Complejo Hospitalario Universitario de Albacete  Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Mas Romero","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Complejo Hospitalario Universitario de Albacete  Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa Bel\u00e9n","family":"Cort\u00e9s Zamora","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Complejo Hospitalario Universitario de Albacete  Albacete Spain"},{"name":"CIBERFES Ministerio de Econom\u00eda y Competitividad  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Tabernero Sahuquillo","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Complejo Hospitalario Universitario de Albacete  Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Romero Rizos","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Complejo Hospitalario Universitario de Albacete  Albacete Spain"},{"name":"CIBERFES Ministerio de Econom\u00eda y Competitividad  Madrid Spain"},{"name":"Facultad de Medicina Universidad de Castilla\u2010La Mancha  Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Manuel","family":"S\u00e1nchez\u2010Jurado","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Complejo Hospitalario Universitario de Albacete  Albacete Spain"},{"name":"CIBERFES Ministerio de Econom\u00eda y Competitividad  Madrid Spain"},{"name":"Facultad de Medicina Universidad de Castilla\u2010La Mancha  Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gin\u00e9s","family":"S\u00e1nchez\u2010Nievas","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Complejo Hospitalario Universitario de Albacete  Albacete Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Campayo Escolano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Complejo Hospitalario Universitario de Albacete  Albacete 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