{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:21:27Z","timestamp":1793830887312,"version":"4.6.1"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postoperative delirium (POD) is a frequently observed complication after transcatheter aortic valve replacement (TAVR). The effects of intraoperative hypotension (IOH) on POD occurrence are currently unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective observational cohort study of patients who underwent TAVR was conducted. We predefined IOH as area under the threshold (AUT) of five mean arterial blood pressures (MBP), varying from &lt;100 to &lt;60\u2009mmHg. The AUT consisted of the combination of duration and depth under the MBP thresholds, expressed in mmHg*min. All MBP AUTs were computed based on the complete procedure, independent of procedural phase or duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This cohort included 675 patients who underwent TAVR under general anesthesia (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009128, 19%) or procedural sedation (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u2009547, 81%). Delirium occurred mostly during the first 2\u2009days after TAVR, and was observed in\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u200993 (14%) cases. Furthermore, 674, 672, 663, 630, and 518 patients had at least 1\u2009min intraoperative MBP &lt;100, &lt;90, &lt;80, &lt;70, and &lt;60\u2009mmHg, respectively. Patients who developed POD had higher AUT based on all five MBP thresholds during TAVR. The penalized adjusted odds ratio varied between 1.08 (99% confidence interval [CI] 0.74\u20131.56) for the AUT based on MBP\u2009&lt;\u2009100\u2009mmHg and OR 1.06 (99% CI 0.88\u20131.28) for the AUT based on MBP\u2009&lt;\u200960\u2009mmHg.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Intraoperative hypotension is frequently observed during TAVR, but not independently associated with POD after TAVR. Other potential factors than intraoperative hypotension may explain the occurrence of delirium after TAVR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.17361","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T12:06:52Z","timestamp":1633694812000},"page":"3177-3185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Intraoperative hypotension and delirium among older adults undergoing transcatheter aortic valve replacement"],"prefix":"10.1111","volume":"69","author":[{"given":"Esther M.","family":"Wesselink","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, University Medical Center Utrecht Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3628-9304","authenticated-orcid":false,"given":"Masieh","family":"Abawi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nynke H. 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