{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:16:17Z","timestamp":1788369377034,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["254627"],"award-info":[{"award-number":["254627"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["303169"],"award-info":[{"award-number":["303169"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["572604"],"award-info":[{"award-number":["572604"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The dose\u2013response relationship of vitamin D status and the risk of serious falls requiring hospitalization in older women is unclear. We examined the association between plasma 25\u2010hydroxyvitamin D (25OHD) with falls\u2010related hospitalizations over 14.5\u2009years in a large cohort of older women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In 1348 community\u2010dwelling Australian women aged \u226570\u2009years, plasma 25OHD concentrations were assessed at baseline (1998) using LC\u2013MS\/MS. Fall\u2010related hospitalizations were obtained from linked data systems. Baseline grip strength and timed\u2010up\u2010and\u2010go (TUG) were assessed as measures of muscle strength and physical function, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean plasma 25OHD was 66.9\u2009\u00b1\u200928.2\u2009nmol\/L. The number of women in the low (LOW; &lt;50\u2009nmol\/L), medium (MED; 50 to &lt;75\u2009nmol\/L), and higher 25OHD (HIGH; \u226575\u2009nmol\/L) categories were 384 (28.5%), 491 (36.4%), and 473 (35.1%), respectively. In the multivariable\u2010adjusted analysis, compared to LOW, women in HIGH had significantly lower hazards for a falls\u2010related hospitalization (HR 0.76 95%CI 0.61\u20130.95). Restricted cubic spline regression models highlight increasing gradient of risk for a falls\u2010related hospitalization with decreasing 25OHD levels. Generalized additive modeling highlighted higher 25OHD to be associated with better TUG performance. Including TUG into the multivariable\u2010adjusted models did not alter the relationship between 25OHD and injurious falls (HIGH vs. LOW HR 0.76 95%CI 0.60\u20130.95).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In community\u2010dwelling older Australian women, maintaining plasma 25OHD at 75\u2009nmol\/L or above may confer benefits to muscle function and long\u2010term prevention of injurious falls requiring hospitalization. This relationship appears to be independent of better physical function observed in women with higher 25OHD levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.17442","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T05:42:52Z","timestamp":1631252572000},"page":"3114-3123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association between vitamin D status and long\u2010term falls\u2010related hospitalization risk in older women"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5166-0605","authenticated-orcid":false,"given":"Marc","family":"Sim","sequence":"first","affiliation":[{"name":"Institute for Nutrition Research, School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Medical School University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8723-7574","authenticated-orcid":false,"given":"Kun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Medical School University of Western Australia  Perth Western Australia Australia"},{"name":"Department of Endocrinology and Diabetes Sir Charles Gairdner Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua R.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Institute for Nutrition Research, School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Medical School University of Western Australia  Perth Western Australia Australia"},{"name":"Centre for Kidney Research, Children's Hospital at Westmead School of Public Health, Sydney Medical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Hodgson","sequence":"additional","affiliation":[{"name":"Institute for Nutrition Research, School of Medical and Health Sciences Edith Cowan University  Joondalup Western Australia Australia"},{"name":"Medical School University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Prince","sequence":"additional","affiliation":[{"name":"Medical School University of Western Australia  Perth Western Australia Australia"},{"name":"Department of Endocrinology and Diabetes Sir Charles Gairdner Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2001.24893"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03404525"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112134"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.03142.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03733.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1637-7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.16.1999"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2017.03.015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12631"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.15006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.02949.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1193"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30265-1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000584"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b3692"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.123"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.8.869"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01317.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.052936"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH080766"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2005.07.002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx115"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01616.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.2000.tb00520.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50012.x"},{"key":"e_1_2_10_27_1","volume-title":"Energy, Nutrition and Human Performance","author":"McArdle WD","year":"1991"},{"key":"e_1_2_10_28_1","volume-title":"Health and Fitness through Physical Activity","author":"Pollock ML","year":"1978"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-13-58"},{"key":"e_1_2_10_30_1","volume-title":"Dietary Reference Intakes for Calcium and Vitamin D","author":"Institute of Medicine","year":"2010"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3841"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0071-8"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1285-3"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3818"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0510"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2017.09.012"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51510.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00468.x"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2562"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30269-9"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1525"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1215"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2004.19.2.265"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(01)00547-1"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.173"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afh209"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0749-1"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/32.3.315"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2013.02.009"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.12.013"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws141"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-008-0026-4"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.17442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgs.17442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.17442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:32:34Z","timestamp":1762187554000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.17442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,10]]},"references-count":52,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/jgs.17442"],"URL":"https:\/\/doi.org\/10.1111\/jgs.17442","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,10]]},"assertion":[{"value":"2021-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}