{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T23:59:08Z","timestamp":1780963148486,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K76AG059929"],"award-info":[{"award-number":["K76AG059929"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>One in five older adults (age 65+) uses an antidepressant medication. However, little is known about how fall risk differs between commonly prescribed medications. We examine the comparative association between individual selective serotonin reuptake inhibitors (SSRI) and self\u2010reported falls in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We used data from 2010\u20132017 Medicare Current Beneficiary Surveys, a nationally representative survey of Medicare beneficiaries. We included participants from three different panels surveyed over two successive years. Participants were limited to community\u2010dwelling Medicare beneficiaries 65+, enrolled in Medicare Part D, and taking an SSRI (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01023) during baseline years. Participants were asked about demographic and health characteristics, medication use (including dose, frequency, duration of use) and self\u2010reported falls as any fall or recurrent falls in the past year. We compared individual SSRI (citalopram or escitalopram vs sertraline) use by the average monthly total standardized daily dose (TSDD) and self\u2010reported falling, controlling for potential confounders. Descriptive analysis and multivariable logistic regressions were conducted using SAS\u2010callable SUDAAN.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Citalopram\/escitalopram (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0460 users; 45.0% of all SSRI users) and sertraline (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0294 users; 28.7% of all SSRI users) were the most commonly prescribed SSRIs. Overall, 36.3% of citalopram\/escitalopram users and 39.4% of sertraline users reported a fall in the year following medication use. There were no statistically significant differences between sertraline and citalopram\/escitalopram users of either low or medium TSDD levels in the risk of self\u2010reported any or recurrent falls. However, users of high TSDD of sertraline (&gt;75\u2009mg) had a lower risk of recurrent falls compared to high TSDD citalopram (&gt;30\u2009mg) or escitalopram (&gt;15\u2009mg) daily for 30\u2009days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest a potential comparative safety benefit of sertraline compared to citalopram\/escitalopram at high doses related to recurrent falls. Additional comparative studies of individual antidepressants may better inform fall risk management and prescribing for older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.17686","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T03:29:14Z","timestamp":1644290954000},"page":"1450-1460","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A comparative analysis of selective serotonin reuptake inhibitors and fall risk in older adults"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6803-2410","authenticated-orcid":false,"given":"Yara K.","family":"Haddad","sequence":"first","affiliation":[{"name":"Division of Injury Prevention National Center of Injury Prevention and Control, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramakrishna","family":"Kakara","sequence":"additional","affiliation":[{"name":"Division of Injury Prevention National Center of Injury Prevention and Control, Centers for Disease Control and Prevention  Atlanta Georgia USA"},{"name":"Cherokee Nation Operational Solutions, LLC  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary A.","family":"Marcum","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/58.3.m249"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.5706"},{"issue":"10","key":"e_1_2_10_4_1","first-page":"2375","article-title":"Depression in later life: a diagnostic and therapeutic challenge","volume":"69","author":"Birrer RB","year":"2004","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.01.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559827619880529"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsr.2020.11.008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028016644466"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15966"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15767"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.japh.2019.05.001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010027663"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1402180"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102710.2009.01050.x"},{"key":"e_1_2_10_15_1","unstructured":"Centers for Medicare and Medicaid Services. 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