{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:14:22Z","timestamp":1762956862754,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Poor functional status is highly prevalent among older patients hospitalized for HF and marks a downward inflection point in functional and prognostic trajectories. We assessed the prognostic value of 6\u2010min walk test after transitional cardiac rehabilitation in older patients hospitalized for heart failure (HF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied 759 patients aged \u226560\u2009years who had been transferred to six inpatient rehabilitation facilities (IRF) from acute care hospitals after a hospitalization for acute HF. The primary outcome was 3\u2010year all\u2010cause mortality. We used multivariable Cox analysis to determine the association between 6\u2010min walk distance (6MWD) at discharge from the IRFs and the primary outcome, adjusting for established predictors of death. The optimal cutoff for 6MWD was considered as the one that maximized the chi\u2010square statistic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean age was 75\u2009\u00b1\u20098\u2009years. 6MWD significantly increased from admission to discharge (145 to 210\u2009m;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The optimal cutoff for 6MWD was 198\u2009m. After full adjustment, the hazard ratio for each 50\u2009m\u2010increase in discharge 6MWD was 0.90 (0.87\u20130.94;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and that for discharge 6MWD dichotomized at the optimal cutoff 0.48 (0.38\u20130.60;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The incidence rate of death\/100 person\u2010years for the patients who walked &gt;198\u2009m was 13.0 (10.0\u201315.5) compared with 30.8 (26.9\u201335.4) for those who walked &lt;198\u2009m. A statistically significant interaction of discharge 6MWD with left ventricular ejection fraction (EF) on the risk of death was observed (\n                      <jats:italic>p<\/jats:italic>\n                      value for interaction 0.047).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A rehabilitation intervention provided in the critical hospital\u2010to\u2010home transition period to older patients hospitalized for HF resulted in improved functional capacity. Increasing levels of functional capacity following rehabilitation were closely associated with decreasing risk of death; this association was significantly stronger for the subgroup with preserved EF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.17736","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T05:09:31Z","timestamp":1646888971000},"page":"1774-1784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic value of functional capacity after transitional rehabilitation in older patients hospitalized for heart failure"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8535-3264","authenticated-orcid":false,"given":"Domenico","family":"Scrutinio","sequence":"first","affiliation":[{"name":"Department of Cardiac Rehabilitation Istituti Clinici Scientifici Maugeri SpA SB, IRCCS, Institute of Bari  Bari 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