{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:33:38Z","timestamp":1793223218342,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG024824"],"award-info":[{"award-number":["P30 AG024824"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32 AG062043"],"award-info":[{"award-number":["T32 AG062043"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG009740"],"award-info":[{"award-number":["U01 AG009740"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pain, fatigue, and depression frequently co\u2010occur as a symptom cluster. While commonly occurring in those with cancer and autoimmune disease, the cluster is also found in the absence of systemic illness or inflammation. Loneliness is a common psychosocial stressor associated with the cluster cross\u2010sectionally. We investigated whether loneliness predicted the development of pain, fatigue, depression, and the symptom cluster over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Data from the Health and Retirement Study were used. We included self\u2010respondents \u226550\u2009year\u2010old who had at least two measurements of loneliness and the symptom cluster from 2006\u20132016 (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05974). Time\u2010varying loneliness was used to predict pain, fatigue, depression, and the symptom cluster in the subsequent wave(s) using generalized estimating equations (GEE) and adjusting for sociodemographic covariates, living arrangement, and the presence of the symptom(s) at baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Loneliness increased the odds of subsequently reporting pain (aOR 1.22, 95% CI 1.08, 1.37), fatigue (aOR 1.47, 95% CI 1.32, 1.65), depression (aOR 2.33, 95% CI 2.02, 2.68), as well as the symptom cluster (aOR 2.15, 95% CI 1.74, 2.67). The median time between the baseline and final follow\u2010up measurement was 7.6\u2009years (IQR 4.1, 8.2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Loneliness strongly predicts the development of pain, fatigue, and depression as well as the cluster of all three symptoms several years later in a large, nonclinical sample of older American adults. Future studies should examine the multiple pathways through which loneliness may produce this cluster, as well as examine whether other psychosocial stressors also increase risk. It is possible that interventions which address loneliness in older adults may prevent or mitigate the cluster of pain, fatigue, and depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.17796","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T01:14:32Z","timestamp":1649812472000},"page":"2225-2234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Bad company: Loneliness longitudinally predicts the symptom cluster of pain, fatigue, and depression in older adults"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7108-5449","authenticated-orcid":false,"given":"Victoria D.","family":"Powell","sequence":"first","affiliation":[{"name":"Division of Geriatric and Palliative Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Geriatric Research, Education, and Clinical Center LTC Charles S. Kettles VA Medical Center  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navasuja","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Geriatric and Palliative Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej T.","family":"Galecki","sequence":"additional","affiliation":[{"name":"Division of Geriatric and Palliative Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Biostatistics, School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Kabeto","sequence":"additional","affiliation":[{"name":"Division of Geriatric and Palliative Medicine University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Clauw","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afton","family":"Hassett","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Division of Geriatric and Palliative Medicine University of Michigan  Ann Arbor Michigan USA"},{"name":"Geriatric Research, Education, and Clinical Center LTC Charles S. Kettles VA Medical Center  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2010.10.261"},{"issue":"9","key":"e_1_2_8_3_1","first-page":"64","article-title":"When is it justified to treat symptoms? measuring symptom burden","volume":"16","author":"Cleeland CS","year":"2002","journal-title":"Oncology"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncimonographs\/lgh023"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010019\u201005268\u20100"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010020\u201005522\u20108"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010013\u20101885\u20105"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.12228"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2018.12.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2007.03.017"},{"issue":"4","key":"e_1_2_8_11_1","first-page":"535","article-title":"Clinical features of patients with systemic lupus erythematosus according to health\u2010related quality of life, entity of pain, fatigue and depression: a cluster analysis","volume":"37","author":"Margiotta DPE","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1191\/0269215506cr880oa"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/2333721421997620"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2006.01.008"},{"key":"e_1_2_8_15_1","first-page":"123","volume-title":"Loneliness: A Sourcebook of Current Theory, Research and Therapy","author":"Perlman D","year":"1982"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102012\u2010302755"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182145"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010psych\u2010010814\u2010015240"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1745691614568352"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.17061\/phrp3022008"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.16865"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/02813432.2016.1160628"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0898264317721348"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002082"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0034012"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2014.12.018"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000003033"},{"key":"e_1_2_8_28_1","unstructured":"SmithJ RyanL FisherG SonnegaA WeirD.HRS Psychosocial and Lifestyle Questionnaire 2006\u20132016; 2017.https:\/\/hrs.isr.umich.edu\/publications\/biblio\/9066"},{"issue":"1","key":"e_1_2_8_29_1","first-page":"85","article-title":"Subsidized housing not subsidized health: health status and fatigue among elders in public housing and other community settings","volume":"21","author":"Parsons PL","year":"2011","journal-title":"Ethn Dis"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","unstructured":"SteffickDE.Documentation of Affective Functioning Measures in the Health and Retirement Study.2000.https:\/\/hrs.isr.umich.edu\/sites\/default\/files\/biblio\/dr-005.pdf","DOI":"10.7826\/ISR-UM.06.585031.001.05.0005.2000"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040\u20103590.9.3.233"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0164027504268574"},{"key":"e_1_2_8_33_1","doi-asserted-by":"crossref","unstructured":"ClarkeP FisherG HouseJ SmithJ WeirD.Guide to Content of the HRS Psychosocial Leave\u2010Behind Participant Lifestyle Questionnaires: 2004 &2006. Institute for Social Research. Published 2008. Accessed March 12 2020.http:\/\/hrsonline.isr.umich.edu\/sitedocs\/userg\/HRS2006LBQscale.pdf","DOI":"10.7826\/ISR-UM.06.585031.001.05.0016.2008"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610215001532"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219686110"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531248"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006\u2010341X.2001.00120.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2009.09.005"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6736a2"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0017216"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0018646"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.2.234"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102015\u2010308790"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15746"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.11.016"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1037\/hea0000059"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780195377903.003.0007"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001299"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jabr.12135"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3266"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/00223980.2011.606434"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.17796","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgs.17796","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.17796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T14:36:56Z","timestamp":1762180616000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.17796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,12]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/jgs.17796"],"URL":"https:\/\/doi.org\/10.1111\/jgs.17796","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,12]]},"assertion":[{"value":"2021-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}