{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:36Z","timestamp":1787015616225,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL135273"],"award-info":[{"award-number":["K23HL135273"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["5K24AG065525"],"award-info":[{"award-number":["5K24AG065525"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG047837"],"award-info":[{"award-number":["U01AG047837"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000063","name":"Office of Dietary Supplements","doi-asserted-by":"publisher","award":["P30DK072488"],"award-info":[{"award-number":["P30DK072488"]}],"id":[{"id":"10.13039\/100000063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Orthostatic hypotension (OH) based on a change from seated\u2010to\u2010standing blood pressure (BP) is often used interchangeably with supine\u2010to\u2010standing BP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Study to Understand Fall Reduction and Vitamin D in You (STURDY) was a randomized trial of vitamin D3 supplementation and fall in adults aged \u226570\u2009years at high risk of falls. OH was defined as a drop in systolic or diastolic BP of at least 20 or 10\u2009mmHg, measured at pre\u2010randomization, 3\u2010, 12\u2010, and 24\u2010month visits with each of 2 protocols: seated\u2010to\u2010standing and supine\u2010to\u2010standing. Participants were asked about orthostatic symptoms, and falls were ascertained via daily fall calendar, ad hoc reporting, and scheduled interviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 534 participants with 993 paired supine and seated assessments (mean age 76\u2009\u00b1\u20095\u2009years, 42% women, 18% Black), mean baseline BP was 130\u2009\u00b1\u200919\/68\u2009\u00b1\u200911\u2009mmHg; 62% had a history of high BP or hypertension. Mean BP increased 3.5 (SE, 0.4)\/2.6 (SE, 0.2) mmHg from sitting to standing, but decreased with supine to standing (mean change: \u22123.7 [SE, 0.5]\/\u22120.8 [SE, 0.3] mmHg;\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value\u2009&lt;\u20090.001). OH was detected in 2.1% (SE, 0.5) of seated versus 15.0% (SE, 1.4) of supine assessments (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). While supine and seated OH were not associated with falls (HR: 1.55 [0.95, 2.52] vs 0.69 [0.30, 1.58]), supine systolic OH was associated with higher fall risk (HR: 1.77 [1.02, 3.05]). Supine OH was associated with self\u2010reported fainting, blacking out, seeing spots and room spinning in the prior month (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010values\u2009&lt;\u20090.03), while sitting OH was not associated with any symptoms (\n                      <jats:italic>P<\/jats:italic>\n                      \u2010values\u2009\u2265\u20090.40).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Supine OH was more frequent, associated with orthostatic symptoms, and potentially more predictive of falls than seated OH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.17804","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T03:55:32Z","timestamp":1650599732000},"page":"2310-2319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Comparison of supine and seated orthostatic hypotension assessments and their association with falls and orthostatic symptoms"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4168-2696","authenticated-orcid":false,"given":"Stephen P.","family":"Juraschek","sequence":"first","affiliation":[{"name":"Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence J.","family":"Appel","sequence":"additional","affiliation":[{"name":"Divison of General Internal Medicine The Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Epidemiology The Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"The Welch Center for Prevention, Epidemiology and Clinical Research The Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8211-281X","authenticated-orcid":false,"given":"Christine","family":"M. 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