{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:37:41Z","timestamp":1787877461692,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["19\/IFA\/7409"],"award-info":[{"award-number":["19\/IFA\/7409"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Age\u2010related morbidities and frailty are associated with impaired blood pressure (BP) and heart rate (HR) recovery after standing. Here we investigate how multimorbidity affects cerebral and peripheral hemodynamics during standing in a large sample of older patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients were recruited from a national Falls and Syncope Unit. They underwent an active stand test (5\u201310\u2009min lying +3\u2009min standing) with monitoring of continuous BP, HR, total peripheral resistance (TPR), stroke volume (SV), and a near\u2010infrared spectroscopy (NIRS) derived cerebral tissue saturation index (TSI). A multimorbidity count was derived from a 26\u2010item list of conditions. Features derived from the signals included: nadir, overshoot, value at 30\u2009s, steady\u2010state and recovery rate. Robust linear regression was used to assess the association between multimorbidity, TSI and peripheral hemodynamics while correcting for covariates. A\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value &lt;0.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multimorbidity was associated with poorer recovery of TSI at 30\u2009s after standing (\u03b2: \u22120.15, CI:[\u22120.25\u20130.06],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.009) independent of all peripheral hemodynamics. Impaired diastolic BP (DBP) recovery at 30s (\u03b2:\u22121.34, CI:[\u22122.29\u20130.40],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.032), DBP steady\u2010state (\u03b2:\u22121.18, CI:[\u22122.04\u20130.32],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.032), TPR overshoot\u2010to\u2010nadir difference (\u03b2:\u22120.041, CI:[\u22120.070\u20130.013],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.045), and SV at 30s (\u03b2:1.30, CI:[0.45 2.15],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.027) were also associated with increasing multimorbidity. After sex stratification, only females demonstrated impaired TSI with multimorbidity at overshoot (\u03b2: \u22120.19, CI: [\u22120.32 \u20100.07],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.009), 30\u2009s (\u03b2: \u22120.22 [\u22120.35\u20130.10],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.005) and steady\u2010state (\u03b2: \u22120.20, CI:[\u22120.35\u20130.04],\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u20090.023), independent of peripheral hemodynamics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transient cerebral oxygenation and peripheral hemodynamic responses are impaired with multimorbidity (frailty) in older patients, particularly in females. This study demonstrates the feasibility of using NIRS in this clinical context and may inform the development of clinical management strategies targeting both cerebral oxygenation and blood pressure impairments in patients with faints and falls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.17810","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T05:25:23Z","timestamp":1652160323000},"page":"1973-1986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Increased multimorbidity is associated with impaired cerebral and peripheral hemodynamic stabilization during active standing"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7442-1612","authenticated-orcid":false,"given":"Laura","family":"P\u00e9rez\u2010Denia","sequence":"first","affiliation":[{"name":"School of Medicine Trinity College Dublin  Dublin Ireland"},{"name":"Falls and Syncope Unit Mercer's Institute for Successful Ageing, St. James's Hospital Dublin  Dublin Ireland"},{"name":"Department of Medical Physics Mercer's Institute for Successful Ageing, St. James's Hospital Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Claffey","sequence":"additional","affiliation":[{"name":"School of Medicine Trinity College Dublin  Dublin Ireland"},{"name":"Falls and Syncope Unit Mercer's Institute for Successful Ageing, St. James's Hospital Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Byrne","sequence":"additional","affiliation":[{"name":"Falls and Syncope Unit Mercer's Institute for Successful Ageing, St. James's Hospital Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciara","family":"Rice","sequence":"additional","affiliation":[{"name":"Falls and Syncope Unit Mercer's Institute for Successful Ageing, St. James's Hospital Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose Anne","family":"Kenny","sequence":"additional","affiliation":[{"name":"School of Medicine Trinity College Dublin  Dublin Ireland"},{"name":"Falls and Syncope Unit Mercer's Institute for Successful Ageing, St. James's Hospital Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciar\u00e1n","family":"Finucane","sequence":"additional","affiliation":[{"name":"School of Medicine Trinity College Dublin  Dublin Ireland"},{"name":"Falls and Syncope Unit Mercer's Institute for Successful Ageing, St. James's Hospital Dublin  Dublin Ireland"},{"name":"Department of Medical Physics Mercer's Institute for Successful Ageing, St. James's Hospital Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14563"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010016\u20108375\u2010x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008976"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.117.10542"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15327"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2011.12.009"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967\u20103334\/25\/4\/004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00260.2002"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00171"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux298"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2018.288"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa194"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glaa315"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2020"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.114.009831"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1353\/dem.2005.0011"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2016.12.021"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286\u2010008\u20100465\u20100"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286\u2010019\u201000606\u2010y"},{"key":"e_1_2_11_21_1","doi-asserted-by":"crossref","unstructured":"SuzukiS TakasakiS OzakiT KobayashiY.Tissue oxygenation monitor using NIR spatially resolved spectroscopy. vol 3597. 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