{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:19:15Z","timestamp":1781756355564,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["K08048221"],"award-info":[{"award-number":["K08048221"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG053273"],"award-info":[{"award-number":["R01AG053273"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Research has suggested optimism is associated with healthy aging and exceptional longevity, but most studies were conducted among non\u2010Hispanic White populations. We examined associations of optimism to longevity across racial and ethnic groups and assessed healthy lifestyle as a possible mediating pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants from the Women's Health Initiative (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0159,255) completed a validated measure of optimism and provided other demographic and health data at baseline. We evaluated associations of optimism with increments in lifespan using accelerated failure time models, and with likelihood of exceptional longevity (survival to age \u226590) using Poisson regression models. Causal mediation analysis explored whether lifestyle\u2010related factors mediated optimism\u2010lifespan associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After covariate adjustment, the highest versus lowest optimism quartile was associated with 5.4% (95% confidence interval [CI]\u00a0=\u00a04.5, 6.4%) longer lifespan. Within racial and ethnic subgroups, these estimates were 5.1% (95%CI\u00a0=\u00a04.0, 6.1%) in non\u2010Hispanic White, 7.6% (95%CI\u00a0=\u00a03.6, 11.7%) in Black, 5.4% (95%CI\u00a0=\u00a0\u22120.1, 11.2%) in Hispanic\/Latina, and 1.5% (95% CI\u00a0=\u00a0\u22125.0, 8.5) in Asian women. A high proportion (53%) of the women achieved exceptional longevity. Participants in the highest versus lowest optimism quartile had greater likelihood of achieving exceptional longevity (e.g., full sample risk ratio\u00a0=\u00a01.1, 95%CI\u00a0=\u00a01.1, 1.1). Lifestyle mediated 24% of the optimism\u2010lifespan association in the full sample, 25% in non\u2010Hispanic White, 10% in Black, 24% in Hispanic\/Latina, and 43% in Asian women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher optimism was associated with longer lifespan and a greater likelihood of achieving exceptional longevity overall and across racial and ethnic groups. The contribution of lifestyle to these associations was modest. Optimism may promote health and longevity in diverse racial and ethnic groups. Future research should investigate these associations in less long\u2010lived populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.17897","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T05:04:03Z","timestamp":1654664643000},"page":"2793-2804","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Optimism, lifestyle, and longevity in a racially diverse cohort of women"],"prefix":"10.1111","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9716-2502","authenticated-orcid":false,"given":"Hayami K.","family":"Koga","sequence":"first","affiliation":[{"name":"Department of Social and Behavioral Sciences Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9989-4259","authenticated-orcid":false,"given":"Claudia","family":"Trudel\u2010Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Social and Behavioral Sciences Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Lee Kum Sheung Center for Health and Happiness Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"},{"name":"Department of Psychology Universit\u00e9 du Qu\u00e9bec \u00e0 Trois\u2010Rivi\u00e8res, and the Research Center of Institut Universitaire en Sant\u00e9 Mentale de Montr\u00e9al  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-8198","authenticated-orcid":false,"given":"Lewina O.","family":"Lee","sequence":"additional","affiliation":[{"name":"National Center for Posttraumatic Stress Disorder at VA Boston Healthcare System  Boston Massachusetts USA"},{"name":"Department of Psychiatry Boston University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2858-1973","authenticated-orcid":false,"given":"Peter","family":"James","sequence":"additional","affiliation":[{"name":"Department of Population Medicine Harvard Medical School and Harvard Pilgrim Health Care Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6128-3118","authenticated-orcid":false,"given":"Candyce","family":"Kroenke","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente  Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-761X","authenticated-orcid":false,"given":"Lorena","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences School of Medicine, University of California\u2010Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-0522","authenticated-orcid":false,"given":"Aladdin H.","family":"Shadyab","sequence":"additional","affiliation":[{"name":"Department of Family Medicine and Public Health University of California, San Diego School of Medicine  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4636-8698","authenticated-orcid":false,"given":"Elena","family":"Salmoirago\u2010Blotcher","sequence":"additional","affiliation":[{"name":"Brown University School of Medicine  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9426-7595","authenticated-orcid":false,"given":"JoAnn E.","family":"Manson","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Epidemiology Harvard T.H. 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