{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:54:43Z","timestamp":1762178083983,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["5U13AG054139"],"award-info":[{"award-number":["5U13AG054139"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This report summarizes the presentations, discussions, and recommendations of the most recent American Geriatrics Society and National Institute on Aging research conference, \u201cCancer and Cardiovascular Disease,\u201d on October 18\u201319, 2021. The purpose of this virtual meeting was to address the interface between cancer and heart disease, which are the two leading causes of death among older Americans. Age\u2010related physiologic changes are implicated in the pathogenesis of both conditions. Emerging data suggest that cancer\u2010related cardiovascular disease (CVD) involves disrupted cell signaling and cellular senescence. The risk factors for CVD are also risk factors for cancer and an increased likelihood of cancer death, and people who have both cancer and CVD do more poorly than those who have only cancer or only CVD. Issues addressed in this bench\u2010to\u2010bedside conference include mechanisms of cancer and CVD co\u2010development in older adults, cardiotoxic effects of cancer therapy, and management of comorbid cancer and CVD. Presenters discussed approaches to ensure equitable access to clinical trials and health care for diverse populations of adults with CVD and cancer, mechanisms of cancer therapy cardiotoxicity, and management of comorbid CVD and cancer, including the role of patient values and preferences in treatment decisions. Workshop participants identified many research gaps and questions that could lead to an enhanced understanding of comorbid CVD and cancer and to better and more equitable management strategies.<\/jats:p>","DOI":"10.1111\/jgs.17921","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T04:19:56Z","timestamp":1654921196000},"page":"2764-2774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<scp>AGS<\/scp>\n                    and\n                    <scp>NIA<\/scp>\n                    bench\u2010to bedside conference summary: Cancer and cardiovascular disease"],"prefix":"10.1111","volume":"70","author":[{"given":"Supriya","family":"Mohile","sequence":"first","affiliation":[{"name":"Department of Medicine University of Rochester Medical Center  Rochester New York United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline S.","family":"Blaum","sequence":"additional","affiliation":[{"name":"Department of Medicine National Committee for Quality Assurance  Washington District of Columbia United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Abadir","sequence":"additional","affiliation":[{"name":"Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Dale","sequence":"additional","affiliation":[{"name":"Department of Supportive Care Medicine City of Hope National Medical Center  Duarte California United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E.","family":"Forman","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Department of Medicine Pittsburgh Geriatric Research Education and Clinical Center  Pittsburgh Pennsylvania United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunkit","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Rochester Medical Center  Rochester New York United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly M.","family":"Holmes","sequence":"additional","affiliation":[{"name":"University of Texas McGovern Medical School  Houston Texas United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javid","family":"Moslehi","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco  San Francisco California United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M.","family":"Mustian","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Rochester Medical Center  Rochester New York United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Rich","sequence":"additional","affiliation":[{"name":"Department of Medicine Washington University School of Medicine  St. Louis Missouri United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather E.","family":"Whitson","sequence":"additional","affiliation":[{"name":"Department of Medicine Duke University  Durham North Carolina United States"},{"name":"Durham VA Geriatrics Research, Education, and Clinical Center  Durham North Carolina United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz058"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw604"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz766"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010020\u20100964\u20107"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.64.0409"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.20.00721"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40959\u2010021\u201000110\u20101"},{"key":"e_1_2_13_9_1","unstructured":"American Geriatrics Society. 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