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These efforts include adoption of non\u2010opioid pain medication including gabapentin. Like opioids, gabapentin use may be prolonged, increasing the risk of altered mental status and even overdose and death when taken concurrently with opioids. However, little is known about postoperative prolonged use of gabapentin in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We merged a 20% sample of Medicare Carrier, MedPAR and Outpatient Files with Part D for 2013\u20132018. We included patients &gt;65\u2009years old without prior gabapentinoid use who underwent common non\u2010cataract surgical procedures. We defined new postoperative gabapentin as fills for 7\u2009days before surgery until 7\u2009days after discharge. We excluded patients whose discharge disposition was hospice or death. The primary outcome was prolonged use of gabapentin, defined as a fill&gt;90\u2009days after discharge. To identify risk factors for prolonged use, we constructed logistic regression models, adjusted for procedure and patient characteristics, length of stay, disposition location, and care complexity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 17,970 patients (3% of all eligible patients) had a\n                      <jats:italic>new<\/jats:italic>\n                      prescription for gabapentin after surgery. Of these, the mean age was 73\u2009years old and 62% were female. The most common procedures were total knee (45%) and total hip (21%) replacements. Prolonged use occurred in 22%. Those with prolonged use were more likely to be women (64% vs. 61%), be non\u2010White (14% vs. 12%), have concurrent prolonged opioid use (44% vs. 18%), and have undergone emergency surgery (8% vs. 4%). On multivariable analysis, being female, having a higher Charlson comorbidity score, having an opioid prescription at discharge and at &gt;90\u2009days and having a higher care complexity were associated with prolonged use of gabapentin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>More than one\u2010fifth of older adults prescribed gabapentin postoperatively filled a prescription &gt;90\u2009days after discharge, especially among patients with more comorbidities and concurrent prolonged opioid use, increasing the risk of adverse drug events and polypharmacy.<\/jats:p>\n                  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San Francisco School of Medicine  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Boscardin","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco School of Medicine  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9564-9480","authenticated-orcid":false,"given":"Michael A.","family":"Steinman","sequence":"additional","affiliation":[{"name":"Division of Geriatrics University of California San Francisco School of Medicine  San Francisco California USA"},{"name":"Department of Medicine San Francisco VA Medical Center  San Francisco California 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