{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T18:49:13Z","timestamp":1784400553384,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prevalence of postural tremor increases with age and the tremor has been found to be associated with aging\u2010related physiological decline. However, whether postural tremor in older adults is associated with adverse outcomes such as disability is unclear. This study investigated the association between postural tremor and the risk of disability in activities of daily living (ADL) among community\u2010dwelling older people.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were derived from a population\u2010based study of Chinese adults aged \u226555\u2009years. Postural tremor was assessed at baseline using a two\u2010step method (i.e., tremor screening followed by examination of positive cases). ADL disability was determined using an 8\u2010item questionnaire, which covered the mobility and self\u2010care domains of ADL. Participants free of ADL disability at baseline were followed for up to 4\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prospective analyses included 5868 participants. Participants with postural tremor were at greater risk of incident ADL disability, particularly disability in the mobility domain of ADL. After multivariate adjustment, postural tremor was not significantly associated with incident ADL disability (multivariate\u2010adjusted relative risk [RR]\u00a0=\u00a01.05, 95% confidence interval [CI]\u00a0=\u00a00.77\u20131.43), and was marginally associated with incident disability in the mobility domain of ADL (multivariate\u2010adjusted RR\u00a0=\u00a01.36, 95% CI\u00a0=\u00a00.98\u20131.88). The risk of mobility\u2010related ADL disability was significantly increased among men, but not women, with postural tremor (multivariate\u2010adjusted RR\u00a0=\u00a01.84, 95% CI\u00a0=\u00a01.11\u20133.05). Older age and an increased number of chronic comorbidities mainly explained the higher risk of ADL disability in older people with postural tremor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Postural tremor in older adults is associated with greater incidence of ADL disability, particularly mobility\u2010related ADL disability. The association is largely due to older age and a higher prevalence of chronic comorbidities in older people with postural tremor. Postural tremor is not a strong independent predictor of ADL disability in older people.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.18139","type":"journal-article","created":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T12:25:17Z","timestamp":1670070317000},"page":"1220-1227","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between postural tremor and risk of disability in community\u2010dwelling older people"],"prefix":"10.1111","volume":"71","author":[{"given":"Xitong","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurology, Geriatrics, and Neurobiology National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Geriatrics, and Neurobiology National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8958-3825","authenticated-orcid":false,"given":"Shaozhen","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurology, Geriatrics, and Neurobiology National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuqin","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Geriatrics, and Neurobiology National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University  Beijing China"},{"name":"Clinical Center for Parkinson's Disease Capital Medical University, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key 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