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We sought to determine the incidence of new psychotropic medication use among community\u2010dwelling PWD after hospital discharge and, among new users, the proportion with prolonged use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cohort study using a 20% random sample of Medicare claims in 2017, including hospitalized PWD with traditional and Part D Medicare who were 68\u2009years or older. The primary outcome was incident prescribing at discharge of psychotropics including antipsychotics, sedative\u2010hypnotics, antiepileptics, and antidepressants. This was defined as new prescription fills (i.e., from classes not used in 180\u2009days preadmission) within 7\u2009days of hospital or skilled nursing facility discharge. Prolonged use was defined as the proportion of new users who continued to fill newly prescribed medications beyond 90\u2009days of discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort included 117,022 hospitalized PWD with a mean age of 81\u2009years; 63% were female. Preadmission, 63% were using at least 1 psychotropic medication; 10% were using medications from \u22653 psychotropic classes. These included antidepressants (44% preadmission), antiepileptics (29%), sedative\u2010hypnotics (21%), and antipsychotics (11%). The proportion of PWD discharged from the hospital with new psychotropics ranged from 1.9% (antipsychotics) to 2.9% (antiepileptics); 6.6% had at least one new class started. Among new users, prolonged use ranged from 36% (sedative\u2010hypnotics) to 63% (antidepressants); across drug classes, prolonged use occurred in 51%. Predictors of newly initiated psychotropics included length of stay (\u2265median vs. &lt;median; aOR 1.5, 95% CI: 1.4\u20131.6) and delirium (aOR 1.8, 95% CI: 1.7\u20131.9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hospitalized PWD have a high prevalence of preadmission psychotropic medication use; against this baseline, discharge from the hospital with new psychotropics is relatively uncommon. Nevertheless, prolonged use of newly initiated psychotropics occurs in a substantial proportion of this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.18161","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:17:10Z","timestamp":1670977030000},"page":"1134-1144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["New psychotropic medication use among Medicare beneficiaries with dementia after hospital discharge"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5997-4406","authenticated-orcid":false,"given":"Matthew E.","family":"Growdon","sequence":"first","affiliation":[{"name":"Division of Geriatrics University of California  San Francisco California USA"},{"name":"Geriatrics, Palliative, and Extended Care Service Line San Francisco VA Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Gan","sequence":"additional","affiliation":[{"name":"Division of Geriatrics University of California  San Francisco California USA"},{"name":"Northern California Institute for Research and Education  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"Mental Health San Francisco VA Medical Center  San Francisco California USA"},{"name":"Department of Epidemiology and Biostatistics University of California  San Francisco California USA"},{"name":"Departments of Neurology and Psychiatry University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9525-3833","authenticated-orcid":false,"given":"Alexandra K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Geriatrics University of California  San Francisco California USA"},{"name":"Geriatrics, Palliative, and Extended Care Service Line San Francisco VA Medical Center  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-275X","authenticated-orcid":false,"given":"Timothy S.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of General Medicine Beth Israel Deaconess Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0754-664X","authenticated-orcid":false,"given":"Ulrike","family":"Muench","sequence":"additional","affiliation":[{"name":"Department of Social and Behavioral Sciences School of Nursing, University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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