{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:21:19Z","timestamp":1762190479246,"version":"build-2065373602"},"reference-count":51,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000128"],"award-info":[{"award-number":["UL1 TR000128"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["U01 AR45580","U01 AR45583","U01 AR45614","U01 AR45632","U01 AR45647","U01 AR45654"],"award-info":[{"award-number":["U01 AR45580","U01 AR45583","U01 AR45614","U01 AR45632","U01 AR45647","U01 AR45654"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1K76 AG074903","1R03 AG067937","P30 AG044281","R01 AG066671","U01 AG027810","U01 AG18197"],"award-info":[{"award-number":["1K76 AG074903","1R03 AG067937","P30 AG044281","R01 AG066671","U01 AG027810","U01 AG18197"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Life\u2010space mobility represents the distance, frequency, and independence of mobility, ranging from one's bedroom to beyond their town. Older men with lower urinary tract symptoms (LUTS) may limit their life\u2010space to stay close to a bathroom. However, it's unknown whether LUTS severity or urinary bother are associated with risk of life\u2010space mobility restriction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from 3025 community\u2010dwelling men age \u226571\u2009years without life\u2010space mobility restriction at analytic baseline (Year 7) of the Osteoporotic Fractures in Men (MrOS) study. The American Urologic Association Symptom Index (AUASI) was assessed at baseline and includes one question assessing urinary bother (\u201cIf you were to spend the rest of your life with your urinary condition just the way it is now, how would you feel about that?\u201d; score 0\u20131,2,3,4\u20136) and seven items to classify LUTS severity as none\/mild (score 0\u20137), moderate (8\u201319), or severe (20\u201335). The University of Alabama Life\u2010space Assessment was used to define life\u2010space mobility restriction (\u226460) at baseline and follow\u2010up (Year 9). We used log\u2010binomial regression with robust variance estimators to model adjusted risk ratios (ARR) for LUTS severity and urinary bother with incident life\u2010space mobility restriction, controlling for age, site, health\u2010related factors, and comorbidities. We then mutually adjusted for urinary bother and LUTS severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, the 2\u2010year risk of life\u2010space mobility restrictions was 9.9%. Compared to men without urinary bother (scores 0\u20131), the risk of life\u2010space mobility restriction was significantly higher among men with bother scores of 4\u20136 (ARR\u00a0=\u00a02.20, 95% CI: 1.52, 3.19), independent of LUTS severity and confounders. Conversely, LUTS severity was not independently associated with the risk of life\u2010space mobility restriction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Urinary bother, but not LUTS severity, is independently associated with incident life\u2010space mobility restriction among older men. To maintain life\u2010space mobility in older men with LUTS, future studies should identify shared mechanisms and interventions that minimize urinary bother.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.18171","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T23:21:09Z","timestamp":1671146469000},"page":"1093-1104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lower urinary tract symptom severity, urinary bother, and incident\n                    <scp>life\u2010space<\/scp>\n                    mobility restriction among older men"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4908-1924","authenticated-orcid":false,"given":"Scott R.","family":"Bauer","sequence":"first","affiliation":[{"name":"Department of Medicine University of California  San Francisco California USA"},{"name":"Department of Urology University of California  San Francisco California USA"},{"name":"Department of Medicine San Francisco VA Healthcare System  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thu","family":"Le","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University\u2010Portland State University School of Public Health  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9069-3036","authenticated-orcid":false,"given":"Kristine E.","family":"Ensrud","sequence":"additional","affiliation":[{"name":"Department of Medicine and Division of Epidemiology and Community Health University of Minnesota  Minneapolis Minnesota USA"},{"name":"Center for Care Delivery and Outcomes Research Veterans Affairs Health Care System  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4938-9478","authenticated-orcid":false,"given":"Peggy M.","family":"Cawthon","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California  San Francisco California USA"},{"name":"Research Institute California Pacific Medical Center  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Newman","sequence":"additional","affiliation":[{"name":"Buck Institute for Research on Aging  Novato California USA"},{"name":"Division of Geriatrics, Department of Medicine University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Suskind","sequence":"additional","affiliation":[{"name":"Department of Urology University of California  San Francisco California 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