{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T09:59:08Z","timestamp":1782640748227,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["10430 01 201 0011: IRIS"],"award-info":[{"award-number":["10430 01 201 0011: IRIS"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients over 70\u2009years old represent a substantial proportion of the COVID\u201019 ICU population and their mortality rates are high.<\/jats:p>\n                    <jats:p>The aim of this study is to describe the outcomes of patients \u226570\u2009years old admitted to Dutch ICUs with COVID\u201019, compared to patients \u226570\u2009years old admitted to the ICU for bacterial and other viral pneumonias, with adjustments for age, comorbidities, severity of illness, and ICU occupancy rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study including patients \u226570\u2009years old admitted to Dutch ICUs, comparing patients admitted with COVID\u201019 from March 1st 2020 to January 1st 2022 with patients \u226570\u2009years old admitted because of a bacterial and other viral pneumonia, both divided in a historical (i.e., January 1st 2017 to January 1st 2020) and current cohort (i.e., March 1st 2020 to January 1st 2022). Primary outcome is hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      11,525 unique patients \u226570\u2009years old admitted to Dutch ICUs were included; 5094 with COVID\u201019, 5334 with a bacterial pneumonia, and 1312 with another viral pneumonia. ICU\u2010mortality and in\u2010hospital mortality rates of the patients \u226570\u2009years old admitted with COVID\u201019 were 39.7% and 47.6% respectively. ICU\u2010 and hospital mortality rates of the patients who were admitted in the same or in an historical time period with a bacterial pneumonia or other viral pneumonias were considerably lower (19.5% and 28.6% for patients with a bacterial pneumonia in the historical cohort and 19.1% and 28.8% in the same period, for the patients with other viral pneumonias 20.7% and 28.9%, and 22.7% and 31.8% respectively, all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Differences persisted after correction for several clinical characteristics and ICU occupancy rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In ICU\u2010patients \u226570\u2009years old, COVID\u201019 is more severe compared to bacterial or viral pneumonia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.18220","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T03:13:51Z","timestamp":1675826031000},"page":"1440-1451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Increased mortality in\n                    <scp>ICU<\/scp>\n                    patients \u226570\u2009years old with\n                    <scp>COVID<\/scp>\n                    \u201019 compared to patients with other pneumonias"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3120-6891","authenticated-orcid":false,"given":"Lenneke E. M.","family":"Haas","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine Diakonessenhuis  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Termorshuizen","sequence":"additional","affiliation":[{"name":"Amsterdam UMC location University of Amsterdam Department of Medical Informatics  Amsterdam The Netherlands"},{"name":"Amsterdam Public Health Quality of Care &amp; Methodology  Amsterdam The Netherlands"},{"name":"National Intensive Care Evaluation (NICE) foundation  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corstiaan A.","family":"den Uil","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Maasstad Hospital  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette F.","family":"de Keizer","sequence":"additional","affiliation":[{"name":"Amsterdam UMC location University of Amsterdam Department of Medical Informatics  Amsterdam The Netherlands"},{"name":"Amsterdam Public Health Quality of Care &amp; Methodology  Amsterdam The Netherlands"},{"name":"National Intensive Care Evaluation (NICE) foundation  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0191-7270","authenticated-orcid":false,"given":"Dylan W.","family":"de Lange","sequence":"additional","affiliation":[{"name":"National Intensive Care Evaluation (NICE) foundation  Amsterdam the Netherlands"},{"name":"Department of Intensive Care Medicine University Medical Center, Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Dutch COVID\u201019 Research Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2002032"},{"key":"e_1_2_13_3_1","first-page":"157","article-title":"WHO declares COVID\u201019 a pandemic","volume":"91","author":"Cucinotta D","year":"2020","journal-title":"Acta Biomed"},{"key":"e_1_2_13_4_1","unstructured":"World Health Organization:WHO Coronavirus (COVID\u201019) Dashboard [Internet]. 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