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While frailty has been shown to be a risk factor, it has yet to be studied as a therapeutic target to improve outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This trial sought to determine the effects of an in\u2010hospital multicomponent intervention targeting physical weakness, cognitive impairment, malnutrition, and anemia on patient\u2010centered outcomes compared to usual care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010center parallel\u2010group randomized clinical trial was conducted in older patients with acute CVD and evidence of frailty or pre\u2010frailty as measured by the Essential Frailty Toolset (EFT). Patients were randomized to usual care or a multicomponent intervention. Outcomes were HRQOL (EQ\u20105D\u20105L score) and disability (Older Americans Resources and Services score) at 30\u2009days post\u2010discharge and mood disturbances (Hospital Anxiety and Depression Scale) at discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The trial cohort consisted of 142 patients with a mean age of 79.5\u2009years and 55% females. The primary diagnosis was heart failure in 29%, valvular heart disease in 28%, ischemic heart disease in 14%, arrhythmia in 11%, and other CVDs in 18%. The intervention improved HRQOL scores (coefficient 0.08; 95% CI 0.01, 0.15;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03) and mood scores (coefficient \u22121.95; 95% CI \u22123.82, \u22120.09;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.04) but not disability scores (coefficient 0.18; 95% CI \u22121.44, 1.81;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.82). There were no intervention\u2010related adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In frail older patients hospitalized for acute CVDs, an in\u2010hospital multicomponent intervention targeted to frailty was safe and led to modest yet clinically meaningful improvements in HRQOL and mental well\u2010being. The downstream impact of these effects on event\u2010free survival and functional status remains to be evaluated in future research, as does the generalizability to other healthcare systems.<\/jats:p>\n                    <jats:p>Clinical registration number: NCT04291690.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.18228","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T08:18:36Z","timestamp":1673857116000},"page":"1406-1415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Multicomponent intervention for frail and pre\u2010frail older adults with acute cardiovascular conditions: The\n                    <scp>TARGET\u2010EFT<\/scp>\n                    randomized clinical trial"],"prefix":"10.1111","volume":"71","author":[{"given":"Rosie","family":"Fountotos","sequence":"first","affiliation":[{"name":"Division of Experimental Medicine McGill University  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