{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T06:46:19Z","timestamp":1773989179438,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL135273"],"award-info":[{"award-number":["K23HL135273"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["T32DK007732"],"award-info":[{"award-number":["T32DK007732"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG047837"],"award-info":[{"award-number":["U01AG047837"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000063","name":"Office of Dietary Supplements","doi-asserted-by":"publisher","award":["P30DK072488"],"award-info":[{"award-number":["P30DK072488"]}],"id":[{"id":"10.13039\/100000063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      To assess whether vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      supplementation attenuates the decline in daily physical activity in low\u2010functioning adults at risk for falls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Secondary data analyses of STURDY (Study to Understand Fall Reduction and Vitamin D in You), a response\u2010adaptive randomized clinical trial. Participants included 571 adults aged 70\u2009years and older with baseline serum 25(OH)D levels of 10\u201329\u2009ng\/mL and elevated fall risk, who wore a wrist accelerometer at baseline and at least one follow\u2010up visit and were randomized to receive: 200\u2009IU\/day (control), 1000, 2000, or 4000\u2009IU\/day of vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      . Objective physical activity quantities and patterns (total daily activity counts, active minutes\/day, and activity fragmentation) were measured for 7\u2010days, 24\u2010h\/day, in the free\u2010living environment using the Actigraph GT9x over up to 24\u2010months of follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In adjusted models, physical activity quantities declined (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and became more fragmented, or \u201cbroken up\u201d, (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.017) over time. Supplementation with vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      did not attenuate this decline. Changes in physical activity were more rapid among those with baseline serum 25(OH)D &lt;20\u2009ng\/mL compared to those with baseline 25(OH)D levels of 20\u201329\u2009ng\/mL (time*baseline 25(OH)D,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In low\u2010functioning older adults with serum 25(OH)D levels 10\u201329\u2009ng\/mL, vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      supplementation of 1000\u2009IU\/day or higher did not attenuate declines in physical activity compared with 200\u2009IU\/day. Those with baseline 25(OH)D &lt;20\u2009ng\/mL showed accelerated declines in physical activity. Alternative interventions to supplementation are needed to curb declines in physical activity in older adults with low serum 25(OH)D.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.18290","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T14:49:52Z","timestamp":1677163792000},"page":"2208-2218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The association of vitamin D supplementation and serum vitamin D levels with physical activity in older adults: Results from a randomized trial"],"prefix":"10.1111","volume":"71","author":[{"given":"Jennifer A.","family":"Schrack","sequence":"first","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"Center on Aging and Health Johns Hopkins University and Medical Institutions  Baltimore Maryland 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Health  Baltimore Maryland USA"},{"name":"Center on Aging and Health Johns Hopkins University and Medical Institutions  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8211-281X","authenticated-orcid":false,"given":"Christine M.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"},{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research Johns Hopkins University and Medical Institutions  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Edgar R.","family":"Miller","sequence":"additional","affiliation":[{"name":"Welch Center for Prevention, Epidemiology, and Clinical Research Johns Hopkins University and Medical Institutions  Baltimore Maryland USA"},{"name":"Division of General Internal Medicine Johns Hopkins School of Medicine  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