{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:27:51Z","timestamp":1792686471041,"version":"4.5.0"},"reference-count":80,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Medication\u2010related osteonecrosis of the jaw (MRONJ) is clinically defined as a non\u2010healing jawbone ulcerative\u2010necrotic lesion appearing after dental therapy or minor trauma in patients treated previously with anti\u2010resorptive, anti\u2010angiogenic or immunomodulators. Older patients with osteoporosis and cancer receive these pharmacological agents regularly. As these patients are long\u2010term survivors, efficient treatment is of paramount importance for their quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Literature searches via PubMed were conducted to identify relevant MRONJ studies. Basic information on MRONJ classification, clinical features, and pathosphysiology is presented herein as well as various clinical studies dealing with MRONJ in patients with osteoporosis and cancer. Lastly, we discuss current managment of patients and new trends in treatment of MRONJ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although close follow\u2010up and local hygiene have been advocated by some authors, severe forms of MRONJ are not responsive to conservative therapy. At present, there is no \u201cgold standard\u201d therapy for this condition. However, as the physiopathological basis of MRONJ is represented by the anti\u2010angiogenic action of various pharmacological agents, new methods to increase and promote local angiogenesis and vascularization have recently been successfully tested in vitro, limited preclinical studies, and in a pilot clinical study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>It appears that the best method implies application on the lesion of endothelial progenitor cells as well as pro\u2010angiogenic factors such as Vascular Endothelial Growth Factor (VEGF) and other related molecules. More recently, scaffolds in which these factors have been incorporated have shown positive results in limited trials. However, these studies must be replicated to include a large number of cases before any official therapeutic protocol is adopted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.18414","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T15:39:00Z","timestamp":1684942740000},"page":"2640-2652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Medication\u2010related osteonecrosis of the jaw: A disease of significant importance for older patients"],"prefix":"10.1111","volume":"71","author":[{"given":"Bridget","family":"Boston","sequence":"first","affiliation":[{"name":"Griffith University School of Medicine and Dentistry Gold Coast Campus, Parklands Drive, Griffith University  Nathan Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Ipe","sequence":"additional","affiliation":[{"name":"Griffith University School of Medicine and Dentistry Gold Coast Campus, Parklands Drive, Griffith University  Nathan Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Capitanescu","sequence":"additional","affiliation":[{"name":"Department Anatomy University of Medicine, and Pharmacy  Craiova Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5641-9631","authenticated-orcid":false,"given":"Andrei","family":"Gresita","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences New York Institute of Technology  Old Westbury New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1283-3395","authenticated-orcid":false,"given":"Stephen","family":"Hamlet","sequence":"additional","affiliation":[{"name":"Griffith University School of Medicine and Dentistry Gold Coast Campus, Parklands Drive, Griffith University  Nathan Queensland 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