{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T18:50:18Z","timestamp":1775587818335,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) has consistently been associated with a higher risk of incident dementia. Observational evidence has suggested catheter ablation may be associated with a lower risk of dementia in patients with AF, but further research is needed. The objectives of this study were to use a global health research network to examine associations between catheter ablation, incident dementia and mortality in older adults with AF, and amongst subgroups by age, sex, co\u2010morbidity status, and oral anticoagulant use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The research network primarily included healthcare organizations in the United States. This network was searched on 28th September 2022 for patients aged \u226565\u2009years with a diagnosis of AF received at least 5\u2009years prior to the search date. Cox proportional hazard models were run on propensity\u2010score matched cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After propensity score matching, 20,746 participants (mean age 68\u2009years; 59% male) were included in each cohort with and without catheter ablation. The cohorts were well balanced for age, sex, ethnicity, co\u2010morbidities, and cardiovascular medications received. The risk of dementia was significantly lower in the catheter ablation cohort (Hazard Ratio 0.52, 95% confidence interval: 0.45\u20130.61). The catheter ablation cohort also had a lower risk of all\u2010cause mortality (Hazard Ratio 0.58, 95% confidence interval: 0.55\u20130.61). These associations remained in subgroup analyses in individuals aged 65\u201379\u2009years, \u226580\u2009years, males, females, participants who received OACs during follow\u2010up, participants with paroxysmal and non\u2010paroxysmal AF, and participants with and without hypertension, diabetes mellitus, ischemic stroke, chronic kidney disease and heart failure, including heart failure with preserved ejection fraction and heart failure with reduced ejection fraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The observed lower risk of dementia and mortality with catheter ablation could be an important consideration when determining appropriate patient\u2010centered rhythm control strategies for patients with AF. Further studies including data on the success of ablation are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.18538","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T04:01:39Z","timestamp":1692763299000},"page":"3357-3366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Catheter ablation and lower risk of incident dementia and mortality in older adults with atrial fibrillation"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8846-0946","authenticated-orcid":false,"given":"Stephanie L.","family":"Harrison","sequence":"first","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool Liverpool John Moores University &amp; Liverpool Heart and Chest Hospital  Liverpool UK"},{"name":"Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences University of Liverpool  Liverpool UK"},{"name":"Registry of Senior Australians South Australian Health and Medical Research Institute  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin J. R.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool Liverpool John Moores University &amp; Liverpool Heart and Chest Hospital  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Austin","sequence":"additional","affiliation":[{"name":"TriNetX LLC  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre A.","family":"Lane","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool Liverpool John Moores University &amp; Liverpool Heart and Chest Hospital  Liverpool UK"},{"name":"Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences University of Liverpool  Liverpool UK"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool Liverpool John Moores University &amp; Liverpool Heart and Chest Hospital  Liverpool UK"},{"name":"Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences University of Liverpool  Liverpool UK"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.05.063"},{"key":"e_1_2_13_3_1","first-page":"e105","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019","volume":"7","year":"2022","journal-title":"Lancet"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055018"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007301"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz386"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.2029"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.772582"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2029980"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2029554"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa726"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n2182"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2013.01.013"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.12.016"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02035.x"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2022.09.007"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318236f0cf"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988706297086"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17884"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afab248"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15568"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux220"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2012.686543"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018675"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027448"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw087"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015740"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707855"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0693"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.05.012"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000665"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.18538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:02:39Z","timestamp":1762182159000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.18538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,23]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/jgs.18538"],"URL":"https:\/\/doi.org\/10.1111\/jgs.18538","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,23]]},"assertion":[{"value":"2023-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}