{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:58:15Z","timestamp":1789570695983,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood pressure (BP) postural changes, both orthostatic hypotension (OHYPO) and orthostatic hypertension (OHYPER) are common in older adults. Few studies have investigated their association with cognition, particularly for OHYPER, an emerging cardiovascular risk factor. We aimed to assess the association between OHYPO, OHYPER and cognition in non\u2010institutionalized older subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The S.AGES (Sujets \u00c2GES, Aged Subjects) cohort followed every 6 months for 3\u2009years non\u2010institutionalized subjects aged \u226565\u2009years without dementia at inclusion, in France. OHYPO and OHYPER were respectively defined as a fall or an increase of \u226520\u2009mmHg in systolic BP and\/or\u2009\u226510\u2009mmHg in diastolic BP after standing from a sitting position. Cognition was assessed using the Mini\u2010Mental State Examination (MMSE). Linear mixed models were used for the analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 3170 subjects included (mean age 78\u2009years, 56% women), 209 (6.5%) had OHYPO and 226 (7.1%) had OHYPER at baseline. After adjustment for demographics, cardiovascular risk factors and disease, seated SBP\/DBP and BP lowering treatment, mean MMSE was 0.52 point lower in participants with OHYPER compared to those with normal BP postural changes (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      adjusted [95% CI]\u2009=\u2009\u22120.52 [\u22120.96; \u22120.09],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) and 0.50 point lower in participants with OHYPO compared to those with normal BP postural changes (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      adjusted [95% CI]\u2009=\u2009\u22120.50 [\u22120.95; \u22120.06],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). Sensitivity analyses showed a dose\u2013response relationship between OHYPO and cognition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although the absolute differences in MMSE were small, both OHYPO and OHYPER were associated with lower cognition. Orthostatic BP measurements could help identify patients with risk of cognitive impairment. Further studies are needed to assess whether controlling orthostatic BP could be a promising interventional target in preserving cognition among older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.18571","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T09:13:10Z","timestamp":1693559590000},"page":"3721-3730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Orthostatic hypotension and orthostatic hypertension are both associated with lower cognitive function: The\n                    <scp>S.AGES<\/scp>\n                    cohort"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-2206","authenticated-orcid":false,"given":"M.","family":"Strumia","sequence":"first","affiliation":[{"name":"Maintain Aging Research Team, CERPOP Universit\u00e9 de Toulouse, Inserm, Universit\u00e9 Paul Sabatier  Toulouse France"},{"name":"D\u00e9partement de pharmacie Clinique, p\u00f4le g\u00e9riatrie Centre Hospitalier Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Vidal","sequence":"additional","affiliation":[{"name":"EA 4468, Universit\u00e9 de Paris  Paris France"},{"name":"Service de g\u00e9riatrie, H\u00f4pital Broca, AP\u2010HP H\u00f4pitaux Universitaires Paris Centre  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Cestac","sequence":"additional","affiliation":[{"name":"Maintain Aging Research Team, CERPOP Universit\u00e9 de Toulouse, Inserm, Universit\u00e9 Paul Sabatier  Toulouse France"},{"name":"D\u00e9partement de pharmacie Clinique, p\u00f4le g\u00e9riatrie Centre Hospitalier Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sallerin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pharmacie Clinique, p\u00f4le g\u00e9riatrie Centre Hospitalier Universitaire de Toulouse  Toulouse France"},{"name":"RESTORE UMR 1301, Inserm 5070, CNRS EFS, \u00e9quipe FLAMES, Universit\u00e9 Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Hanon","sequence":"additional","affiliation":[{"name":"EA 4468, Universit\u00e9 de Paris  Paris France"},{"name":"Service de g\u00e9riatrie, H\u00f4pital Broca, AP\u2010HP H\u00f4pitaux Universitaires Paris Centre  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rouch","sequence":"additional","affiliation":[{"name":"Maintain Aging Research Team, CERPOP Universit\u00e9 de Toulouse, Inserm, Universit\u00e9 Paul Sabatier  Toulouse France"},{"name":"D\u00e9partement de pharmacie Clinique, p\u00f4le g\u00e9riatrie Centre Hospitalier Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the S.AGES Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.5.1123"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt086"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14340"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875\u2010020\u201001313\u20108"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13596"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000235"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S72316"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07334"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010017\u20100228\u20100"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09048"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010161228"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14050"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ\u201009\u20100286"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.224"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371\u2010019\u20100180\u20104"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13095"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly061"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2515\/therapie\/2013043"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010420"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.5.1470"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.01.009"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2017.1368539"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ancard.2017.04.003"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0000000000000251"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2016.08.005"},{"key":"e_1_2_11_27_1","unstructured":"American Psychiatric Association ed.Diagnostic and Statistical Manual of Mental Disorders: DSM\u2010IV; Includes ICD\u20109\u2010CM Codes Effective 1. 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