{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:59:58Z","timestamp":1790787598638,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["20CDA35310455"],"award-info":[{"award-number":["20CDA35310455"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K76AG064428"],"award-info":[{"award-number":["K76AG064428"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL139813"],"award-info":[{"award-number":["R01HL139813"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG062582"],"award-info":[{"award-number":["R01AG062582"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01CX001636"],"award-info":[{"award-number":["I01CX001636"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malnutrition may be an important geriatric condition in adults with heart failure with preserved ejection fraction (HFpEF), but studies on its prevalence and associated clinical outcomes are limited. The aim of this study was to determine if malnutrition is associated with short\u2010term morbidity and mortality in ambulatory patients with HFpEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined 231 patients with a clinical diagnosis of HFpEF seen at two dedicated academic HFpEF programs (Weill Cornell Medicine and Michigan Medicine) from June 2018 to April 2022. Malnutrition was defined by Mini\u2010Nutritional Assessment Short Form (MNA\u2010SF) scores \u226411. The primary endpoint was a 6\u2010month composite of all\u2010cause mortality and all\u2010cause hospitalization. A Cox proportional\u2010hazard models was used to examine the association between malnutrition and the primary endpoint, adjusting for race, prior hospitalization history, and the validated Meta\u2010Analysis Global Group in Chronic (MAGGIC) heart failure prognostic risk score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age of the cohort was 73\u2009years (interquartile range 64\u201381). The most common comorbid conditions included hypertension (prevalence 81%), atrial fibrillation (43%), and obesity (63%). The prevalence of malnutrition was 42% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200997), and MNA\u2010SF scores did not significantly correlate with body mass index (\n                      <jats:italic>R<\/jats:italic>\n                      \u2009=\u2009\u22120.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.71). At the 6\u2010month follow\u2010up, 62 patients (26.8%) were hospitalized and four patients died (1.7%). In a fully\u2010adjusted analysis, malnutrition was independently associated with the composite outcome of all\u2010cause mortality and all\u2010cause hospitalization (HR 1.94 [95% CI: 1.17\u20133.20],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite a high prevalence of obesity, two out of five ambulatory adults with HFpEF are malnourished. Malnutrition was independently associated with adverse outcomes at 6\u2009months. Future work is necessary to develop interventions that can address malnutrition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.18590","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T13:37:22Z","timestamp":1694698642000},"page":"3367-3375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Malnutrition in heart failure with preserved ejection fraction"],"prefix":"10.1111","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3884-1158","authenticated-orcid":false,"given":"Omar","family":"Zainul","sequence":"first","affiliation":[{"name":"Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Perry","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Michigan Frankel Cardiovascular Center  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pan","sequence":"additional","affiliation":[{"name":"Division of Cardiology Harbor\u2010UCLA Medical Center  West Carson California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lau","sequence":"additional","affiliation":[{"name":"Program for the Care and Study of the Aging Heart, Department of Medicine Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Zarzuela","sequence":"additional","affiliation":[{"name":"Program for the Care and Study of the Aging Heart, Department of Medicine Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Kim","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Konerman","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Michigan Frankel Cardiovascular Center  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Hummel","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Michigan Frankel Cardiovascular Center  Ann Arbor Michigan USA"},{"name":"Division of Cardiology VA Ann Arbor Health System  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-3737","authenticated-orcid":false,"given":"Parag","family":"Goyal","sequence":"additional","affiliation":[{"name":"Program for the Care and Study of the Aging Heart, Department of Medicine Weill Cornell Medicine  New York New York 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