{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:38:48Z","timestamp":1788057528056,"version":"build-2784847793"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["agsjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Age is a major risk factor for venous thromboembolism (VTE), yet patients aged \u226590\u2009years are under\u2010represented in clinical trials of anticoagulant therapy. The objectives were to describe and compare patient clinical characteristics, treatments, and outcomes (VTE recurrence, bleeding, and mortality) during the first 3\u2009months of anticoagulation between VTE patients aged \u226590\u2009years and those aged &lt;90\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed data from the Registro Informatizado Enfermedad TromboEmb\u1f40lica (RIETE), an ongoing global observational registry of patients with objectively confirmed acute VTE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From January 2001 to October 2022, 96,701 patients were registered in RIETE, of whom 3262 (3.4%) were aged \u226590\u2009years. Patients aged \u226590\u2009years were less likely to be men, and to have experienced cancer or recent surgery, but more likely to manifest immobility, chronic heart failure, anemia, renal insufficiency, or dementia than those aged &lt;90\u2009years. Most (99.6%) patients aged \u226590\u2009years were receiving anticoagulant therapy. During the first 3\u2009months, 26 patients aged \u226590\u2009years developed VTE recurrences, 116 experienced major bleeding, and 564 died. Among patients initially presenting with pulmonary embolism (PE), deaths due to PE exceeded those due to fatal bleeding (76 vs. 19). Among those initially presenting with isolated deep\u2010vein thrombosis (DVT), it was the reverse (2 vs. 11 deaths).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients aged \u226590\u2009years, the difference in the outcome of anticoagulant treatment depending on the initial presentation of VTE could suggest a need for different management approaches. Clinical trials evaluating the optimal duration of anticoagulation according to initial VTE presentation are warranted to limit excess deaths in this particular population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.18626","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T23:35:30Z","timestamp":1697067330000},"page":"113-125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anticoagulation and venous thromboembolism in patients aged 90\u2009years and older: Data from the\n                    <scp>RIETE<\/scp>\n                    registry"],"prefix":"10.1111","volume":"72","author":[{"given":"Ludovic","family":"Lafaie","sequence":"first","affiliation":[{"name":"D\u00e9partement de G\u00e9rontologie Clinique CHU de Saint\u2010Etienne  Saint\u2010Etienne France"},{"name":"INSERM, UMR1059, Equipe Dysfonction Vasculaire et H\u00e9mostase Universit\u00e9 Jean\u2010Monnet  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Poenou","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Vasculaire et Th\u00e9rapeutique, CHU de Saint\u2010Etienne  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hanon","sequence":"additional","affiliation":[{"name":"H\u00f4pital Broca, Service de G\u00e9rontologie, Assistance Publique \u2013 H\u00f4pitaux de Paris and EA 4468 Universit\u00e9 de Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"L\u00f3pez\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Universitario, Reina Sof\u00eda  C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Nieto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital General Virgen de la Luz  Cuenca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Universitario La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Porras","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Universitario Joan XXIII de Tarragona  Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Lumbierres","sequence":"additional","affiliation":[{"name":"Respiratory Department Arnau de Vilanova\u2010Santa Mar\u00eda University Hospital, IRB Lleida  Lleida, Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bertoletti","sequence":"additional","affiliation":[{"name":"INSERM, UMR1059, Equipe Dysfonction Vasculaire et H\u00e9mostase Universit\u00e9 Jean\u2010Monnet  Saint\u2010Etienne France"},{"name":"Service de M\u00e9decine Vasculaire et Th\u00e9rapeutique, CHU de Saint\u2010Etienne  Saint\u2010Etienne France"},{"name":"INSERM, CIC1408, CHU de Saint\u2010Etienne  Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Monreal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Germans Trias i Pujol de Badalona Universidad Cat\u00f3lica de Murcia  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the RIETE investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.6.585"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304488"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz405"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001830"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2015.11.026"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmr.2019.01.003"},{"key":"e_1_2_10_8_1","first-page":"1","article-title":"The impact of advanced age on anticoagulant therapy for acute venous thromboembolism","volume":"4","author":"Lafaie L","year":"2022","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302507"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906598"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.004450"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306638"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-9560-11-21"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.726232"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03852.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-06-0390"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH17-07-0511"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2022.04.005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-03-0193"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15533"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH08-12-0827"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2016.07.025"},{"key":"e_1_2_10_24_1","unstructured":"Les anticoagulants en France en 2014: \u00e9tat des lieux synth\u00e8se et surveillance.2014;78."},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1731-3922"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1174-1290"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.08.024"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.13883"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers10100380"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.18626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T11:07:44Z","timestamp":1762168064000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.18626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,10]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/jgs.18626"],"URL":"https:\/\/doi.org\/10.1111\/jgs.18626","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,10]]},"assertion":[{"value":"2023-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}